Before the actual process of cell death is precipitated by enzymes, apoptotic signals must cause regulatory proteins to initiate the apoptosis pathway.

Before the actual discovery of mendelevium, the trivalent state was the most stable one in aqueous solution.

Before the actual trial could be held, Clement persuaded Philip to leave the question of Boniface's guilt to the Council of Vienne, which met in 1311.

Before the 2010 regulations, the complete list of the actual and theoretical varieties also included Pinot de Juillet and Pinot Rosé.

Before starting the actual reading, the reader will typically try to elicit cooperation from the subject, saying something such as, " I often see images that are a bit unclear and which may sometimes mean more to you than to me ; if you help, we can together uncover new things about you.

Before actual work began, three main buildings were demolished: the palace of the Archbishop, the Ordinari Palace and the Baptistry of St. Stephen at the Spring, while the old church of Sta.

Before the English translation of Japanese name to Zeon was canonized by Nippon Sunrise in the late 1990s, it was sometimes translated as Zion or Jion, with the latter being closer to actual pronunciation in Japanese.

Before the market opens on the first day of trading a new futures contract, there is a specification but no actual contracts exist.

Before metrification at the FCC, the procedure to figure HAAT was relatively simple: from the proposed or actual antenna site, either 12 or 16 radials were drawn, and points at 2, 4, 6, 8, and radius along each radial were used.

Before the Romulans open fire, Peter challenges the Romulan commander to a ritual fight-to-the-death ( using an obscure but still valid Romulan law predating their schism with the Vulcans ), in which actual battle is prohibited until the contest is resolved.

Before it was known and recognized as the common colourful plastic toy ( sometimes with water inside the actual hoop ), it used to be made of dried up willow, rattan, grapevines, or stiff grasses.

Before then, it used the traditional regimental system, where regiments were actual combat units.

Before maturity, the actual value of a bond may be greater or less than face value, depending on the interest rate payable and the perceived risk of default.

Before its release, the game was met with derision from some due to Microsoft's marketing department Photoshopping lens flares onto what were supposedly actual game screenshots.

Before modern refrigeration was available, Iceboxes were popular, The problem with an icebox was that the cabinet housing it was large, but the actual refrigerated space was quite small.

Before long, his banter with the audience overtook the actual songs ; he became known more as a comedian than a singer.

Before the actual construction started, the terrain was evenly covered with sand from the Sava and the Danube rivers in an effort to dry out the land and raise it above the reach of flooding and underground streams.

Before studying the actual relocation of Aultsville and its populace, it is important to understand the development of the St. Lawrence Seaway Project first.

Before Habonim was named in spring 1929, Chaim ( actual name Hyman S .) Lipshitz as co-founder, had regular organized meetings of boys at his father's Cheder ( school room ) and they were well established by December 1928.

Before this point in time, the growth of the fireball was due to radiative transport, i. e. thermal x-rays " outpaced " the actual expanding bomb debris.

Before the actual battle, the Filipinos had laid an ambush along a narrow path and carefully concealed themselves in camouflaged pits and trenches, awaiting the unsuspecting American column.

Before the British Invasions, writers in the American comic book industry were known as " ace storytellers but mediocre wordsmiths " because the " actual text " of their comic books were generally subordinate to the plot and storytelling.

Before Persil, laundry soaps consisted of either soap flakes or actual bars of soap.

Before a match, the player chooses three of the characters to use in the actual fights, while the fourth member becomes the designated " Striker ", a character the player summons during battle to help their character out by performing one of their Special Moves against the opponent.

Before beginning the construction, the vertex figure ABCD is obtained by cutting each connected edge at ( in this case ) its midpoint.

Before railway construction on the Continent demanded huge quantities of maleable iron mainly for rails, for which low quality iron sufficed, Wallonia was the only Continental region to follow the British model successfully.

Before the days of blinking electrically lighted road barriers, highway construction zones were marked at night by kerosene fired, pot-bellied torches.

Before construction of the Panama Canal, a stagecoach line owned by Cornelius Vanderbilt's Accessory Transit Company connected the lake with the Pacific across the low hills of the narrow Isthmus of Rivas.

Before the construction of the North Portico, most public events were entered from the South Lawn, which was graded and planted by Thomas Jefferson.

Before major construction could begin Judah traveled back to New York City to raise funds to buy out The Big Four.

Before the advent of VLSI devices, TTL integrated circuits were a standard method of construction for the processors of mini-computer and mainframe processors ; such as the DEC VAX and Data General Eclipse, and for equipment such as machine tool numerical controls, printers and video display terminals.

Before the construction of several tunnels and modern roads that now connect it to Fujisawa, Ofuna and Zushi, on land it could be entered only through narrow artificial passes, among which the seven most important were called, a name sometimes translated as " Kamakura's Seven Mouths ".

Before 1976 the federal tax code favored new construction rather than the reuse of existing, sometimes historical, structures.

Before printed circuits ( and for a while after their invention ), point-to-point construction was used.

Before the construction of Waterloo International terminal in 1990, the vehicles were hoisted individually by the Armstrong lift outside the north wall of Waterloo main line station.

Before the construction of the current Teatro Colón, opera performances were given in several theatres, of which the first Teatro Colón and the Teatro Opera were the most important.

Before the construction of the Clarendon Building, the presses were in the basement of the Sheldonian Theatre, and the compositors could not work when the Theatre was in use for ceremonies.

Before the coming of the mine with construction starting in 1981 the Wopkaimin lived in a subsistence economy.

Before the war a number of 1930s council housing blocks were added to the stock, but it was after the war, partly as result of bomb site redevelopment, that the council housing boom really got into its stride, reaching its peak in the 1960s with the construction of several extensive estates, both by the Metropolitan Borough of Islington and the London County Council.

Before achieving success with his music, Gira worked many jobs in construction and demolition.

Before construction of the Unisphere, three piles were tested for structural integrity and all were found to be sound throughout their entire length.

Before construction could begin on the housing project, the local political climate changed greatly when Norris Poulson was elected mayor of Los Angeles in 1953.

Before the construction of I-90, the city was served by U. S. Route 10, which runs through downtown.

Before the construction of the Betuweroute Highspeed Railway, thorough soil research was performed in 1997.

Before construction of the projected aluminum-extrusion plant could begin, however, it became clear that the war would end soon and that the plant would not be needed.

Before completion of the construction, SAC activated the 351st Strategic Missile Wing at Whiteman on Feb. 1, 1963.

Before the construction of Fort Johnston, British settlements along the Carolina coast lacked fortifications to protect them against pirates and privateers, and numerous Spanish attackers exploited this weakness.

Before the post office was established in 1912, Reedsport was a camp for railroad construction workers.

Before its construction, according to local legend, court was held in a flea-infested abandoned stable.