Before the actual process of cell death is precipitated by enzymes, apoptotic signals must cause regulatory proteins to initiate the apoptosis pathway.

Before the actual discovery of mendelevium, the trivalent state was the most stable one in aqueous solution.

Before the actual trial could be held, Clement persuaded Philip to leave the question of Boniface's guilt to the Council of Vienne, which met in 1311.

Before the 2010 regulations, the complete list of the actual and theoretical varieties also included Pinot de Juillet and Pinot Rosé.

Before starting the actual reading, the reader will typically try to elicit cooperation from the subject, saying something such as, " I often see images that are a bit unclear and which may sometimes mean more to you than to me ; if you help, we can together uncover new things about you.

Before the English translation of Japanese name to Zeon was canonized by Nippon Sunrise in the late 1990s, it was sometimes translated as Zion or Jion, with the latter being closer to actual pronunciation in Japanese.

Before the market opens on the first day of trading a new futures contract, there is a specification but no actual contracts exist.

Before metrification at the FCC, the procedure to figure HAAT was relatively simple: from the proposed or actual antenna site, either 12 or 16 radials were drawn, and points at 2, 4, 6, 8, and radius along each radial were used.

Before the Romulans open fire, Peter challenges the Romulan commander to a ritual fight-to-the-death ( using an obscure but still valid Romulan law predating their schism with the Vulcans ), in which actual battle is prohibited until the contest is resolved.

Before it was known and recognized as the common colourful plastic toy ( sometimes with water inside the actual hoop ), it used to be made of dried up willow, rattan, grapevines, or stiff grasses.

Before then, it used the traditional regimental system, where regiments were actual combat units.

Before maturity, the actual value of a bond may be greater or less than face value, depending on the interest rate payable and the perceived risk of default.

Before actual construction of the building could begin, American Fletcher became the first major Indianapolis bank holding company to be sold to an out-of-state financial institution, agreeing in the spring of 1986 to merge with Ohio's rapidly growing Bank One Corporation.

Before its release, the game was met with derision from some due to Microsoft's marketing department Photoshopping lens flares onto what were supposedly actual game screenshots.

Before modern refrigeration was available, Iceboxes were popular, The problem with an icebox was that the cabinet housing it was large, but the actual refrigerated space was quite small.

Before long, his banter with the audience overtook the actual songs ; he became known more as a comedian than a singer.

Before the actual construction started, the terrain was evenly covered with sand from the Sava and the Danube rivers in an effort to dry out the land and raise it above the reach of flooding and underground streams.

Before studying the actual relocation of Aultsville and its populace, it is important to understand the development of the St. Lawrence Seaway Project first.

Before Habonim was named in spring 1929, Chaim ( actual name Hyman S .) Lipshitz as co-founder, had regular organized meetings of boys at his father's Cheder ( school room ) and they were well established by December 1928.

Before this point in time, the growth of the fireball was due to radiative transport, i. e. thermal x-rays " outpaced " the actual expanding bomb debris.

Before the actual battle, the Filipinos had laid an ambush along a narrow path and carefully concealed themselves in camouflaged pits and trenches, awaiting the unsuspecting American column.

Before the British Invasions, writers in the American comic book industry were known as " ace storytellers but mediocre wordsmiths " because the " actual text " of their comic books were generally subordinate to the plot and storytelling.

Before Persil, laundry soaps consisted of either soap flakes or actual bars of soap.

Before a match, the player chooses three of the characters to use in the actual fights, while the fourth member becomes the designated " Striker ", a character the player summons during battle to help their character out by performing one of their Special Moves against the opponent.

Before entering the service, Pfaff for five years did clerical work with a general merchandising and wholesale firm in New Orleans.

Before the publication of this work most of the trouvère romances appeared in octosyllabic verse.

Before her, erotica written by women was rare, with a few notable exceptions, such as the work of Kate Chopin.

Before the work of Lyell, phenomena such as earthquakes were understood by the destruction that they brought.

Before going to Germany, Evans continued her interest in theological work with a translation of Feuerbach's Essence of Christianity, and while abroad she wrote essays and worked on her translation of Baruch Spinoza's Ethics, which she completed in 1856, but which was not published in her lifetime.

Before he made this change, however, he set to work on his last major project as active partner: The Rock and Roll Hall of Fame in Cleveland, Ohio.

Before the year was over, Brown, who had immediately returned to work with his band following his release, organized a pay-per-view concert following a show at Los Angeles ' Wiltern Theatre, that was well received.

Before came Orphée, later turned into one of his more successful films ; after came La Machine infernale, arguably his most fully realized work of art.

Before commencing work, he returned to the Netherlands to make Industrial Symphony for Philips Electric which is considered to be a film of great technical beauty.

Before the nineteenth century, the scholar Nitsa Ben-Ari notes that his work was shunned like that of converts, then banned as those of a traitor, whose work was not to be studied or translated into Hebrew.

Before purchasing any work supposedly by Schwitters, it is best to consult the Kurt Schwitters Archive at the Sprengel Museum in Hannover, Germany.

Before the advent of copyright, anonymous and pseudonymous publication was a common practice in the sixteenth century publishing world, and a passage in the Arte of English Poesie ( 1589 ), the leading work of literary criticism of the Elizabethan period and an anonymously published work itself, mentions in passing that literary figures in the court who wrote " commendably well " circulated their poetry only among their friends, " as if it were a discredit for a gentleman to seem learned " ( Book 1, Chapter 8 ).

Before his work on Pascal, Wirth had developed Euler and ALGOL W and later went on to develop the Pascal-like languages Modula-2 and Oberon.

Before filming started, producer Martin Ransohoff began to receive phone calls about the Major Dundee ordeal and was told Peckinpah was impossible to work with.

Before filming began, several of the film's stars, including Edward Burns, Barry Pepper, Vin Diesel, Adam Goldberg, Giovanni Ribisi, and Tom Hanks, endured ten days of " boot camp " training and work on the film set to prepare for their roles.

Before Friday night dinner, it is customary to sing two songs, one " greeting " the Shabbat angels into the house and the other consisting of Ecclesiastes 31: 10-31, praising the woman of the house for all the work she has done over the past week.

Before his emigration in autumn 1934, Adorno began work on a Singspiel based on Mark Twain's The Adventures of Tom Sawyer entitled The Treasure of Indian Joe, which he would, however, never complete ; by the time he fled Hitler's Germany Adorno had already written over a hundred opera or concert reviews and an additional fifty critiques of music composition.

Before Ellison could begin work on the show's production bible, a writers ' strike began, running from March 6 to June 24.

( In the future, Selick and Burton would work together in The Nightmare Before Christmas and James and the Giant Peach.

Before his work, it was uncommon to use the word " gender " to refer to anything but grammatical categories.

Before the forty days of Great Lent commence, there is a three-week Pre-Lenten season, to prepare the faithful for the spiritual work they are to accomplish during the Great Fast.

Hofstadter later recognized ( what he saw as ) the influence of Darwinist and other evolutionary ideas upon those with collectivist views, enough to devise a term for the phenomenon, “ Darwinist collectivism .” Before Hofstadter's work the use of the term in English academic journals was quite rare.

In 2006 he began work with Modest Mouse's Isaac Brock on songs that eventually featured on the band's 2007 release, We Were Dead Before the Ship Even Sank.