Before the actual process of cell death is precipitated by enzymes, apoptotic signals must cause regulatory proteins to initiate the apoptosis pathway.

Before the actual discovery of mendelevium, the trivalent state was the most stable one in aqueous solution.

Before the 2010 regulations, the complete list of the actual and theoretical varieties also included Pinot de Juillet and Pinot Rosé.

Before starting the actual reading, the reader will typically try to elicit cooperation from the subject, saying something such as, " I often see images that are a bit unclear and which may sometimes mean more to you than to me ; if you help, we can together uncover new things about you.

Before actual work began, three main buildings were demolished: the palace of the Archbishop, the Ordinari Palace and the Baptistry of St. Stephen at the Spring, while the old church of Sta.

Before the English translation of Japanese name to Zeon was canonized by Nippon Sunrise in the late 1990s, it was sometimes translated as Zion or Jion, with the latter being closer to actual pronunciation in Japanese.

Before the market opens on the first day of trading a new futures contract, there is a specification but no actual contracts exist.

Before metrification at the FCC, the procedure to figure HAAT was relatively simple: from the proposed or actual antenna site, either 12 or 16 radials were drawn, and points at 2, 4, 6, 8, and radius along each radial were used.

Before the Romulans open fire, Peter challenges the Romulan commander to a ritual fight-to-the-death ( using an obscure but still valid Romulan law predating their schism with the Vulcans ), in which actual battle is prohibited until the contest is resolved.

Before it was known and recognized as the common colourful plastic toy ( sometimes with water inside the actual hoop ), it used to be made of dried up willow, rattan, grapevines, or stiff grasses.

Before then, it used the traditional regimental system, where regiments were actual combat units.

Before maturity, the actual value of a bond may be greater or less than face value, depending on the interest rate payable and the perceived risk of default.

Before actual construction of the building could begin, American Fletcher became the first major Indianapolis bank holding company to be sold to an out-of-state financial institution, agreeing in the spring of 1986 to merge with Ohio's rapidly growing Bank One Corporation.

Before its release, the game was met with derision from some due to Microsoft's marketing department Photoshopping lens flares onto what were supposedly actual game screenshots.

Before modern refrigeration was available, Iceboxes were popular, The problem with an icebox was that the cabinet housing it was large, but the actual refrigerated space was quite small.

Before long, his banter with the audience overtook the actual songs ; he became known more as a comedian than a singer.

Before the actual construction started, the terrain was evenly covered with sand from the Sava and the Danube rivers in an effort to dry out the land and raise it above the reach of flooding and underground streams.

Before studying the actual relocation of Aultsville and its populace, it is important to understand the development of the St. Lawrence Seaway Project first.

Before Habonim was named in spring 1929, Chaim ( actual name Hyman S .) Lipshitz as co-founder, had regular organized meetings of boys at his father's Cheder ( school room ) and they were well established by December 1928.

Before this point in time, the growth of the fireball was due to radiative transport, i. e. thermal x-rays " outpaced " the actual expanding bomb debris.

Before the actual battle, the Filipinos had laid an ambush along a narrow path and carefully concealed themselves in camouflaged pits and trenches, awaiting the unsuspecting American column.

Before the British Invasions, writers in the American comic book industry were known as " ace storytellers but mediocre wordsmiths " because the " actual text " of their comic books were generally subordinate to the plot and storytelling.

Before Persil, laundry soaps consisted of either soap flakes or actual bars of soap.

Before a match, the player chooses three of the characters to use in the actual fights, while the fourth member becomes the designated " Striker ", a character the player summons during battle to help their character out by performing one of their Special Moves against the opponent.

Before going to trial, both parties settled out of court with Seattle agreeing to acknowledge ownership rights to the 12th Man slogan to A & M.

Before the Dayton trial only the South Carolina, Oklahoma, and Kentucky legislatures had dealt with anti-evolution laws or riders to educational appropriations bills.

Before the trial concluded, Meinhof was found hanged in her cell in 1976.

Before his death in March 1953, Stalin allegedly had planned the execution of " Doctors Plot " defendants already on trial in Red Square in March 1953, and then he would cast himself as the savior of Soviet Jews by sending them to camps away from the purportedly enraged Russian populace.

Before that, a " test trial " expulsion was performed in November 1941, and the whole operation ended in a pacification operation, combined with expulsions in June / July 1943 which was code named Wehrwolf Action I and II.

Before Becker can pronounce the sentence, Lutze remembers that he killed Becker 17 years ago on the night US troops came close to Dachau, and realizes that Becker, as well as all the men who witnessed his trial, are ghosts.

Before a ruling was even made on the request, Moore held a press conference announcing he would seek a change of venue to Brooklyn, claiming it was impossible for Ferguson to receive a fair trial in a Nassau court due to a " severe underrepresentation of African-Americans on the Nassau County jury panel ".

Before trial he was brought before the Council and urged to confess who had incited him to commit the murder.

Before the trial began, it was discovered that Honora Rieper had never married Herbert Rieper, the man known as her husband.

Before the start of the trial, CNN reported that prosecutors were expected to introduce a controversial police confession signed by Saldívar in which she said she shot Selena " during an argument over accusations from the singer's father that Saldívar stole money from Selena's accounts.

Before the trial, a report was carried to the Parliament " as if some busie men had made use of some ill Arts to extort such confession " that a special Commission of Oyer and Terminer was granted for the trial of these witches.

Before trial, the court granted Flynt's motion for summary judgment on the invasion of privacy claim, and the remaining two charges proceeded to trial.

Before that date, however, some rates were fixed for a trial period commencing in December 1984.

Before participating in a clinical trial, interested volunteers should speak with their doctors, family members, and others who have participated in trials in the past.

Before the trial of the king Hammond addressed a letter to Fairfax and the council of officers.

Before Anwar's trial, Mahathir told the press that he was convinced of Anwar's guilt.

Before he went to prison he published a compte rendu of his trial, which had a still larger circulation than the Discours itself.

Before Picard orders the crew to fire phasers at the craft, Q appears to remind him of humanity's trial and prompts Picard to send an away team to the alien craft.

Before his reported 14 August flight, Whitehead was quoted in a 26 July article in the Minneapolis Journal, credited to the New York Sun, in which he described the first two unmanned trial flights of his machine on 3 May.

Before testimony began in his trial in 1994, Rolling pled guilty to all charges.

Before the Act, a trial for treason short of regicide involved an elaborate and lengthy medieval procedure.

Before the trial starts, the motions can be based on defects in instituting the prosecution, defects in the indictment or information ( which can be challenged at any stage but are generally raised before a trial begins ).