By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By contrast, the Indianapolis Colts — among the most successful franchises in any sport during the 2000s with quarterback Peyton Manning — had a 2-14 record in 2011 because of injuries that prevented Manning from playing.

( 1999 ), Introduction to the Philosophy of Science: A Text By Members of the Department of the History and Philosophy of Science of the University of Pittsburgh, Hacket Publishing Company, Indianapolis, IN.

By 1910, the Interurban was making daily trips between Indianapolis and Crawfordsville with scheduled hourly stops in Brownsburg.

By the early 1850s, Gatling was successful enough in business to offer marriage to Jemima Sanders, 19 years younger than Gatling and the daughter of a prominent Indianapolis physician.

By May 1939, MBS was broadcasting the Indianapolis 500.

By the 2001 General Assembly, held in Indianapolis, 42 percent of delegates present and voting were not native English speakers.

Jim served as the Lap By Lap Announcer for the 1986 and 1987 Indianapolis 500.

By the mid-1910s, Louis Chevrolet had shifted into the racing car industry, partnering with Howard E. Blood of Allegan, Michigan to create the Cornelian, a state-of-the-art racing car, which he used to place 20th in the 1915 Indianapolis 500 automobile race.

By far the largest watershed in the state, the Wabash River drainage area contains the several large cities, including Indianapolis and the extreme western part of Fort Wayne.

By an act of the Indiana state legislature, Indianapolis consolidated with the government of Marion County in 1970.

The Crown Royal Presents the Curtiss Shaver 400 at the Brickyard Powered By BigMachineRecords. com is an annual 400-mile ( 644 km ) NASCAR Sprint Cup points race held at the Indianapolis Motor Speedway in Speedway, Indiana.

By 1860, he was devoted to art full-time and became well known in Indianapolis for his portraits and landscapes.

By the 1910 census, the family was residing at 1145 McLain Street in Indianapolis, Indiana, where Harry's father's occupation was listed as a woodworker at a carriage factory.

By the 1920 census, the family was residing at 2113 Morris Street in Indianapolis, Indiana, where Harry's occupation was listed as a bench worker at an automobile plant.

By winning the race, Giancarlo Baghetti became only the third driver to win his first World Championship race, the other two being Nino Farina, who won the first World Championship race ( the 1950 British Grand Prix ) and Johnnie Parsons, who won the 1950 Indianapolis 500 ( the Indianapolis 500 was part of the World Championship from 1950 to 1960 ), though both Farina and Parsons had competed at future World Championship races before the creation of the championship, while this was Baghetti's first start at a major Grand Prix.

By 1997, all of the original Crosley radio and television properties had been sold off by its successor companies, with the exception of WTHR in Indianapolis, which is still owned by an affiliate of the Dispatch Broadcast Group.

The July 10 headline of the Indianapolis Gazetteer screamed " Former Capitol Corydon Ravaged By Morgan ’ s Raiders ; Two Hoosiers Dead.

By the late 1880s, he was one of the Indianapolis area's leading businessmen with over one hundred employees and $ 200, 000 ($ in 2009 chained dollars ) in annual sales.

By 2004, CFI continued to expand into cities across the United States with the creation of a network of community organizations called " CFI Communities " in cities such as Pittsburgh, Cleveland, Tucson, Tallahassee, FL, Indianapolis, and Fort Lauderdale.

By mid-century its condition had deteriorated and so it was replaced in 1954 with a new structure designed by the Indianapolis architectural firm of Burns and Burns.

By agreement, the IRL is not permitted to race opposite the NASCAR Sprint Cup Series Allstate 400 at the Brickyard at the Indianapolis Motor Speedway.