By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By comparison, Stone Harbor bird sanctuary's allies seem less formidable, for aside from the Audubon Society, they are mostly the snowy, common and cattle egrets and the Louisiana, green, little blue and black-crowned herons who nest and feed there.

By this time there is little doubt but what election plans were complete.

By 1960 there were such schools in all but 4 states.

By themselves they may not be able to save the life on this planet, but without them there would be very little left worth saving.

By saying `` another emotional death '', she reveals that there has been a previous one, although she has not described it in words.

I grinned at him, handed him a couple of dollars and said, `` By the time you get the parking charge figured up, there should be a cigar in it for you ''.

By 335 BC he had returned to Athens, establishing his own school there known as the Lyceum.

By 1840 there were still only ten colonial bishops for the Church of England ; but even this small beginning greatly facilitated the growth of Anglicanism around the world.

By 1903 the Liberals were so dominant that there was no longer an organized opposition in Parliament.

By 1073 there were only two Englishmen in episcopal sees, and by the time of William's death in 1089, there was only one, Wulfstan II of Worcester.

Proof: By symmetry, it suffices to prove that there is some constant c such that for all bitstrings s

By its terms the boundary between Alfred ’ s and Guthrum ’ s kingdoms was to run up the River Thames, to the River Lea ; follow the Lea to its source ( near Luton ); from there extend in a straight line to Bedford ; and from Bedford follow the River Ouse to Watling Street.

By the 1850s when they first came into sustained contact by outside groups, there were estimated 7, 000 Adamanese, divided into the following major groups:

By his zeal and exertions – for there were many conflicting interests to reconcile – he adjusted the affair in a manner at once creditable to his judgment and fortunate for his country.

By the beginning of World War II, many towns and cities had built space, and there were numerous qualified pilots available.

" Caplan comments on the impact of the Supreme Court's decision making it necessary for there to be evidence of guilt in such a plea, " By requiring that there be some evidence of guilt in such a situation, the decision attempts to protect the ' really ' innocent from the temptations to which plea-bargaining and defense attorneys may subject them.

By the end of the 18th century there were no factories or mills and only a few small cottage industries along the border with Zurich.

By the mid-nineteenth century there were Wesleyan, Primitive Methodist, United Free Methodist, Congregationalist, Baptist, Swedenborgian, Unitarian, Roman Catholic and Catholic Apostolic churches in the town.

By the 2nd century there were also famous Christian ascetics, such as Saint Thecla.

By the 15th century there is evidence for the renewed use of lidded cementation crucibles at Zwickau in Germany.

By the 6th century AD there is evidence of the foundation of a Bavarian stem duchy whose leadership was related to the ruling Frankish ( and possibly Alemannic / Swabian ) houses.

By 16: 00, Alexander and Swiftsure were also in sight, although some distance from the main British fleet, and Brueys gave orders to abandon the plan to remain at anchor and instead for his line to set sails, although Blanquet protested the order on the grounds that there were not enough men aboard the French ships to both sail the ships and man the guns.

By 1950, there were only 100, 000 monolingual Bretons, and a rapid decline since, with likely no monolingual speakers left today.