By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By the end of the nineteenth century, in 1893, when the Big Three, Columbia, and Penn were populous centers of learning, Dartmouth graduated only sixty-nine.

By 1404, they were raiding the coast of England, with Welsh troops on board, setting fire to Dartmouth and devastating the coast of Devon.

By 1975 Blake had been awarded honorary doctorates from Rutgers, the New England Conservatory, the University of Maryland, Morgan State University, Pratt Institute, Brooklyn College, and Dartmouth.

By the following month, Wallace " Bunny " Bertram ( a former ski coach at Dartmouth College who had helped build the original rope lift ) took over the operation, and installed a more reliable electric motor.

But still, Samuel Pepys notes in his diary on 19 July 1667: " The Dutch fleete are in great squadrons everywhere still about Harwich, and were lately at Portsmouth ; and the last letters say at Plymouth, and now gone to Dartmouth to destroy our Streights ' fleete lately got in thither ; but God knows whether they can do it any hurt, or no, but it was pretty news come the other day so fast, of the Dutch fleets being in so many places, that Sir W. Batten at table cried, By God, says he, I think the Devil shits Dutchmen.

* Dartmouth College – Dartmouth's in Town Again, Come Stand Up Men, As the Backs Go Tearing By, and Glory to Dartmouth

These songs include " Dartmouth's in Town Again ," " Come Stand Up Men ," " As the Backs Go Tearing By ," and " Glory to Dartmouth "-collectively known as the " Dartmouth Tunes " or " DT's ".

By the mid-1900s, the Dartmouth chapter of Chi Phi was having some issues with its national charter.

By his own account, he " was a farmer's boy and student alternately, or sometimes both at once ," until he graduated with an Master of Arts from Dartmouth College in 1814, after election to the Phi Beta Kappa Society.

By 1881 the River Erme was included in the Dartmouth " Customs Port ".

By the 1760s the English, both at home and in the American colonies, applied the term “ cracker ” to Scots-Irish and English American settlers of the remote southern back country, as noted in a passage from a letter to the Earl of Dartmouth: " I should explain to your Lordship what is meant by Crackers ; a name they have got from being great boasters ; they are a lawless set of rascalls on the frontiers of Virginia, Maryland, the Carolinas, and Georgia, who often change their places of abode.

By this time the archive had also moved to new premises at 1 Queen Anne's Gate Buildings, Dartmouth Street.

By the 1960s, most of the other Ivy League institutions ( Dartmouth, Yale, Princeton, Cornell, and Brown ) had provosts ( or equivalents ), as did other private research universities such as the University of Chicago, Stanford University, Rice University, Massachusetts Institute of Technology, Tufts University, Emory University, Wake Forest University and Duke University.

By 1956, the Dartmouth Skiway was built at Holt's Ledge, replacing Oak Hill as the primary downhill skiing facility for the College.

By 1842, The Dartmouth regularly ran to 40 pages and was printed eight times a year.

By virtue of our roles as stewards, ambassadors, and servants, every year, Green Key helps to run such traditional Dartmouth events as First-Year Orientation, the Bonfire, Homecoming Sweep, Commencement, Green Key Weekend, and many other events including performances, services, and guest speakers.

By failing to do as he was told instantly -- to take out a permit or return the gun to his car -- he had played into Lord's hands.

By 1898, rustling losses had been driven down to the lowest level ever seen in Wyoming.

By the death of his father in 1888 he had come into possession of the family estate and had re-assumed its traditions.

By the time Lilian had been graduated from public school, her parents were doing quite well.

) By the time the streetcar pulled away, he had fallen in love with Paula.

By this time she had learned that it was futile to argue with her young husband, yet the uncomfortable fact remained: the American Congregationalists were sending them as missionaries to the Far East and paying their salaries.

By the age of six young Johnny indicated that he had the call.

By September 1940 the Suite had developed into a collection of six songs, `` four spirituals, a dream, and a lullaby ''.

By now he had become Regius Professor of Modern History at Cambridge and had been honored by the award of the Order of Merit.

By both standards Thomas had the right to be proud.

By June 19, 1788, he had presented himself to its Commander in Chief, the Governor of the Southern Provinces, the Director of the War College -- The Prince.

By 1783 her legions had managed to annex the Crimea amid scenes of wanton cruelty and now, in this second combat with the Crescent, were aiming at suzerainty over all of the Black Sea's northern shoreline.

By this time word had got around that an American doctor was on the premises.

By this time Woodruff had accurately measured Pike as a man of great personal pride, a man who would fly into a towering rage if his integrity were questioned, and who would be anxious to avenge himself.

By 1834 the art of oratory had reached a very high level in the United States as a literary form.

By the time he was under the covers he had forgotten about seeing Kate.

By 1937 he had clarified his intentions to serve his people: `` I have striven for clarity and melodious idiom, but at the same time I have by no means attempted to restrict myself to the accepted methods of harmony and melody.

By the time the film was released we were three million dollars over-spent, war was imminent and the public apparently had forgotten all about Mother Cabrini.

By this time Churchill was not so cordial toward moving Poland westward as he had been at Teheran, where he and Eden had both heartily approved the idea.

By December, 1958, when ' Abdallah Ibrahim became President of the Council, elections had even greater importance.

By 800 social and cultural security had been achieved, at least on a simple plane ; ;

By this time large numbers of the audience had left the hall.