By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By 1950 ( in The Long Goodbye ) he has rented a house on Yucca Avenue and continued at the same place in early 1952 in Playback, the last full-length Chandler Marlowe novel.

By 2003, when an anchor property at Yucca and Vine was sold by the DePietro Family to a New York performing arts school, gentrification had begun in earnest.

By the 1770s, the Green Mountain Boys had become an armed military force and de facto government that prevented New York from exercising its authority in the northeast portion of the Province of New York.

By 1860, as many as 10, 000 prospectors had flocked to the town, then known as Mountain City, and surrounding prospects, but most soon left, many returning back east.

By the time of the first production of Boris Godunov in February 1874, Mussorgsky had taken part in the ill-fated Mlada project ( in the course of which he had made a choral version of his Night on Bald Mountain ) and had begun Khovanshchina.

By December 12, on Boot Mountain, it took ninety minutes to progress three hundred yards.

Having reached the top of Nittany Mountain, and ".... seeing the prairies and noble forest beneath him, cried out to his attendant, ' By heavens, Thompson, I have discovered an empire!

By tradition the Shannon is said to rise in the Shannon Pot, a small pool on the slopes of Cuilcagh Mountain in County Cavan, from where the young river appears as a small trout stream.

By the time the Mountain Men began to arrive in the late 1820s and settlers began to arrive again in the 1860s the people of the Cornville area were a mixed community of Apache ( Dil-ze ' e ) and Yavapai ( Wipukepaya ), though the Apache are thought to have been more numerous on the east side of the Verde River.

By the early 1900s, Berthoud sported a business district on Third Street and Massachusetts and Mountain Avenues.

By the late 1940s, with the successful construction of a ski resort on Big Mountain ( a collaboration between outside developers and local businessmen ) the tourism sector was becoming increasingly important.

By 1886 a railroad had been built to connect the glass factory with the Iron Mountain Railroad at Silica, Missouri.

To the south is the Mountain Loop Highway, a Forest Service Scenic By way which connects to Granite Falls at 56 miles.

The duo's hits included " Ain't No Mountain High Enough ", " Your Precious Love ", " Ain't Nothing Like the Real Thing " and " You're All I Need to Get By ".

By May 2011, the band had been writing and recording new demos at its Witch Mountain studio hideaway in the Hollywood Hills, and began recording their new album at Hollywood Recording Studios.

By this time Merton was a huge success outside the monastery, The Seven Storey Mountain having sold over 150, 000 copies.

By 1935 Scott was firmly established as a popular movie star and, thus, following the release of Rocky Mountain Mystery ( 1935 ), Paramount moved him up from his " B " Western status to a star of " A " features, many on loan out.

Ride, Six By Seven, Mogwai, Bardo Pond, The Flowers of Hell, Yume Bitsu, 7 % Solution, Lockgroove, Luna, Windy & Carl, Five Way Mirror, The Third Eye Foundation, American Analog Set, Black Mountain, Flying Saucer Attack, Asteroid No. 4, The Brian Jonestown Massacre, Colorsound, The Warlocks, Black Rebel Motorcycle Club, The Icarus Line, The Morning After Girls, Scarling, and Wooden Shjips.

By 1982, when nearly all of the nation was served by full-time ABC affiliates and the evening newscast began winning the ratings, the network discontinued the practice and started feeding the news to stations at the conventional time of 6: 30 p. m. ( Eastern / Pacific )/ 5: 30 p. m. ( Central / Mountain ) on weeknights.

By early December 2001 troops from the 10th Mountain Division shared the base with Special Operations Command officers from MacDill Air Force Base in Florida and soldiers of the 82nd Airborne Division from Fort Bragg.

To look for new ideas, Eno turned to his instructional cards, the Oblique Strategies, and began coming up with new ideas as he did with his previous album Taking Tiger Mountain ( By Strategy ).

By the 1730s the Pennsylvanian Great Valley west of South Mountain was open to settlement after treaty cessions and purchases from the Indians.

By 1841 the American Fur Company and the Rocky Mountain Fur Company were in ruins.

An example of phasing in popular music is " The True Wheel " on Brian Eno's album Taking Tiger Mountain ( By Strategy ).

By about 1832, the fur traders had improved the trail along the Platte, North Platte, and Sweetwater rivers to a rough wagon trail from the Missouri River to the Green River in Wyoming, where most of the Rocky Mountain Rendezvous were held.

By the request of the latter, Galdan overthrew the Naqshbandu Black Mountain and installed Afaq as his client ruler there.