By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By this time, portions of Ormsby County had been given over to neighboring counties, reducing the county to Carson City and a few outlying settlements.

By the 6th century the majority of the modern county was part of the East Saxon kingdom.

By 1211 the Livonian province of Metsepole ( now Limbaži district ) and mixed Livonian-Latgallian inhabited county of Idumea ( now Straupe ) was converted to the Roman Catholic faith.

By Eastern Han times, the central government monopolies were repealed in favor of production by commandery and county administrations, as well as private businessmen.

By opening the ports of the county to all nations, and proclaiming full freedom of trade ( 1626 ), the commerce of the city was given great stimulus, the noble families taking part in its mercantile enterprises.

By the 1890s the county contained the following burghs, which were largely outside the county council's jurisdiction:

By 1793, four towns had been added to the county by division of the existing towns:

By the 1860s the towns of Harmony, Knightsville, and Brazil were growing rapidly, due in part to their location along the National Road, and also because of the many coal companies in that section of the county.

By 1951, enrollment stood at 35, 000 and included teachers, county and city employees.

By a treaty with Louis IX of France, he wrested the county of Barcelona from nominal French suzerainty and integrated it into his crown.

By 2030, the county is expected to have a population of about 360, 000.

By votes in the commission, the commissioners are given executive responsibilities for the various county departments, which fall under the categories of " Roads and Transportation ", " Community Development ", " Environmental Services ", " Health and Human Services ", " Technlogy and Land Development ", and " Finance and General Services ".

By 1852, regular rail transportation from Columbia to Baltimore, Philadelphia, Pittsburgh, and Harrisburg made the town the commercial center for the area halfway between the county seats of Lancaster and York.

By contrast, in other municipalities, the sheriff's office may be merged with most or all city-level police departments within a county to form a consolidated city-county or metropolitan police force responsible for general law enforcement anywhere in the county.

By 1810, the county seat was at Denbigh.

By the time of the American Revolution, it was the most populous county in Virginia.

By 2005 non-Hispanic whites were 84. 5 % of the population of the county.

By the late 1950s, although immune from annexation by the bigger cities, the most recent suit by the city of Norfolk against Norfolk County would have taken all of the county land adjoining South Norfolk.

By the time most indentured workers had earned freedom and some rose to common planter status, the wealthiest planter families in the county already controlled the valuable riverfront.

By the late 1950s a majority of those graduating from high school in the county were Mexican American.

By January 1, 1991, almost of oil had been taken from county lands since 1936.

By 1920 only eighty-one people lived in the county, and only twenty-seven farms remained.