By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By combining the talents of a medical man, Dr. Aterman, a biophysicist, Mr. Berkely, and an electronics expert, Dr. Zworykin, this novel technique has been developed which promises to open broad avenues to understanding life processes.

By the end of the novel, the elite cavalry wing is led by a dashing young warrior prince named Artos, whom Sutcliff postulates to be the real Arthur.

By 14 he had already written a short adventure novel called The Black Diamonds which was lost for years until published in 2002.

By the 20th century the novel had come to occupy a canonical space as one of the foundations of modern literature.

By 1912 and 1913, there are beginning to be many films from many American companies that rely on applying novel decoration to the story, rather than supplying any twists to the drama itself to sustain interest.

By understanding the physical and chemical properties of proteins and other macromolecules at the atomic level in various cells in the kidney, novel therapeutic approaches can be designed to combat major renal diseases.

By contrast, the novel and anime series Yōtōden portrays Nobunaga as a literal demon posing as a power-mad warlord.

Apocalyptic fiction generally concerns the disaster itself and the direct aftermath, while post-apocalyptic can deal with anything from the near aftermath ( as in Cormac McCarthy's The Road ) to 375 years in the future ( as in By The Waters of Babylon ) to hundreds or thousands of years in the future, as in Russell Hoban's novel Riddley Walker and Walter M. Miller, Jr .' s A Canticle for Leibowitz.

In the US, the new novels Moscow Club ( 1991 ) by Joseph Finder, Masquerade ( 1996 ) by Gayle Lynds, and The Unlikely Spy ( 1996 ) by Daniel Silva, and in the UK, A Spy By Nature ( 2001 ) by Charles Cumming and Remembrance Day ( 2000 ) by Henry Porter, maintained the spy novel in the post – Cold War world.

By 1935, Wright had completed his first novel, Cesspool, published as Lawd Today ( 1963 ), and in January 1936 his story " Big Boy Leaves Home " was accepted for publication in New Caravan.

She also appeared in ITV's Marple: Ordeal By Innocence, based on the Agatha Christie novel.

Hugh Luke argues that " By ending her story with the picture of the Earth's solitary inhabitant, she has brought nearly the whole weight of the novel to bear upon the idea that the condition of the individual being is essentially isolated and therefore ultimately tragic " ( xvii ).

By the end of the novel, she learns to forgive him.

Author of " The Geography of Nowhere ", " The Long Emergency ", and the " World Made By Hand " novel series.

By the time the soap opera had been cancelled, Collins followed in her sister's footsteps and published her first novel Prime Time ( 1988 ) which became a bestseller despite critical pans.

By its centennial, the novel had been translated into 22 languages such as Swahili, Tamil and Serbo-Croatian.

* Edward makes an appearance in the novel By Right of Arms, by Robyn Carr, as a supporter and friend of the main character.

" By 1835, little of the Mission's assets remained, though the manufacture of hides and tallow continued in full swing as described in Richard Henry Dana's classic novel Two Years Before the Mast.

By the end of the novel, Hari suspects that Dors is a robot, too.

In the R. F. Delderfield novel Long Summer Day ( the first of the A Horseman Riding By trilogy ), Boer War veteran Paul Craddock buys a farm in 1900 or 1901.

By 1748 his novel Clarissa was published in full: two volumes appeared in November 1747, two in April 1748, and three in December 1748.

By the third issue in the fall of 1993 the " Net Surf " column began listing interesting FTP sites, Usenet newsgroups, and email addresses, at a time when the numbers of these things were small and this information was still extremely novel to the public.

Examples: William Faulkner in A Rose for Emily ( Faulkner was an avid experimenter in using unusual points of view-see his Spotted Horses, told in third person plural ); Frank B. Gilbreth and Ernestine Gilbreth Carey in Cheaper By the Dozen ; Frederik Pohl in Man Plus ; and more recently, Jeffrey Eugenides in his novel The Virgin Suicides and Joshua Ferris in Then We Came to the End.

By the time he was 23 he had written five poetry collections and a novel published by Wahlström & Widstrand.

By combining this melodramatic approach with the content of Stowe's novel, Aiken helped to create a powerful visual indictment against the institution of slavery.