Despite extensive attempts to obtain highly pure reagents, serious difficulty was experienced in obtaining reproducible rates of reaction.

Despite serious terrain obstacles, almost three-quarters of all cross-border dry cargo is now transported by road, 105, 251 metric tons in 2005.

Despite its many ( serious ) limitations, including extremely low volume, it has considerable expressive power, the player being able to control attack, duration, volume, and even provide certain subtle effects of swelling of tone and a type of vibrato unique to the clavichord.

Despite the fact that Parsons only contributed two new songs to the album (" In My Hour of Darkness ", " Return of the Grievous Angel "), Parsons was highly enthused with his new sound and seemed to have finally adopted a serious, diligent mindset to his musical career, eschewing most drugs and alcohol during the sessions.

Despite its unpleasantness and expense, a diagnostic fast may be the only effective way to confirm or refute a number of serious forms of hypoglycemia, especially those involving excessive insulin.

Despite the arrival of serious competitors — namely, the Ford Falcon, Chrysler Valiant, and Japanese cars — in the 1960s, Holden's locally produced large six-and eight-cylinder cars remained Australia's top-selling vehicles.

Despite his reputation as a serious composer of large, complex musical structures, some of Brahms's most widely known and most commercially successful compositions during his life were small-scale works of popular intent aimed at the thriving contemporary market for domestic music-making ; indeed, during the 20th century, the influential American critic B. H. Haggin, rejecting more mainstream views, argued in his various guides to recorded music that Brahms was at his best in such works and much less successful in larger forms.

Despite a serious injury which ruled Shearer out for half the season, Dalglish achieved fourth position with the team in the first year of the new Premier League.

Despite serious domestic turmoil, the patriotism engendered by Morocco ’ s participation in the Middle East conflict and by the events in Western Sahara contributed to Hassan ’ s popularity and strengthened his hand politically.

Despite these hindrances, his aim ( and that of his collaborator John Dryden ) was to establish serious opera in England, but these hopes ended with Purcell's early death at the age of 36.

Despite the economy's general expansion after 1983, however, inflation threatened its modest gains, as did serious fiscal and balance-of-payments deficits and the growing debt.

Despite the official government statement that allowed for freedom of the press, this was the first trial of whether or not Dubcek was serious about reforms.

Despite these serious negative effects the measure was deemed necessary as tax revenue from provinces occupied and threatened by rebels had ceased to reach the cash-strapped central government.

Despite this apparent success the underlying problems remained unresolved and had already resulted in the death or serious injury of 30, 000 civilians.

Despite suffering from a serious flare-up of his chronic colitis, Lawrence decided to go, but he became ill while in Geneva, and was rushed to the hospital at Stanford University.

Despite the disdain of sousaphones held by most serious tuba players, a quality modern sousaphone is often a better choice for the high school or semi-pro player due to more stable intonation and less breath effort needed to generate tone.

Despite the continuation of single party politics ( known in this case as the Era of Good Feelings ), serious issues emerged during the election in 1820.

Despite serious cash flow problems, they moved UPI's headquarters from New York City to Washington DC, incurring additional major costs due to construction cost overruns.

Despite his occasional ( if serious ) political setbacks — usually at the hands of his great Machiavellian rival, Louis XI of France — Edward was a popular and very able king.

" Despite a serious preservation effort, The Museum of Arts & Design radically altered the building, which reopened in 2008.

Despite all these notable successes in diagnostics and detection techniques ectopic pregnancy remains a source of serious maternal morbidity and mortality worldwide, especially in countries with poor prenatal care.

Despite an arrest record dating back to the 1920s, Bonanno was never convicted of a serious crime.

Despite undoubted successes, Boleslaus III Wrymouth committed serious political errors, even against Zbigniew of Poland, his half-brother.

Despite a serious mutiny in 588, the army managed to continue the war and even secure a major victory before Martyropolis.

Despite serious initial problems with the Austrian censors who had control over northern Italian theatres at the time, the opera had a triumphant premiere and is considered by many to be the first of the operatic masterpieces of Verdi's middle-to-late career.

Despite the apparent risk, the statistical incidence of injury in supervised training and competition is extremely low.

Despite its small size within Guatemala, many leaders were extremely vocal about their beliefs ( for instance, in their protests and, more importantly, their literature ).

Despite sanitary concerns, its consumption is extremely widespread in cities because it's the most practical and often cheapest way to lunch after fast food.

Despite his humble background, Martok would become extremely popular among other warriors and the civilian population, though Martok had repeatedly stated he had no interest in politics.

Despite the extreme toxicity of the tropanes, they are useful drugs when administered in extremely small dosages.

Despite many development plans and efforts, the state of telecommunication sector in the country remained extremely poor up to 1994.

Despite his growing alcoholism and controversial reputation, Peckinpah was extremely prolific during this period of his life.

Despite its advertised advantage ( quick release ), the slipped constrictor knot can also be hard to release when worked extremely tight in certain rope materials.

Despite his two previous defeats, Bryan remained extremely popular among the more liberal and populist elements of the Democratic Party.

Despite the momentary respite delivered by Isabella, by the autumn of 1321, the tensions between the two factions of Edward, Isabella and the Despenser, opposing the baronial opposition led by Thomas of Lancaster, were extremely high, with forces still mobilised across the country.

Despite a long history of often extremely controversial statements, Robertson has remained a powerful figure both religiously and politically.

Despite the justification of Venetian embroilment in the terraferma that was offered in Foscari's funeral oration, delivered by the humanist senator and historian Bernardo Giustiniani, and some encouraging notable victories, the war was extremely costly to Venice, whose real source of wealth and power was at sea, and to her ally Florence ; they were eventually overcome by the forces of Milan under the leadership of Francesco Sforza.

Despite his macabre sense of humour, he was extremely generous, and would go out of his way to help those whom he considered friends.

Despite his size, her mate, Melatha, was extremely fast and left a trail of sparks as he streaked across the sky.

Despite his acid tongue, he is an extremely kind and caring man who also is greatly fond of Fuchsia and Titus.

Despite its small size, the town's scenic location on a headland surrounded by the Pacific Ocean has made it extremely popular as an artist colony and with vacationers.

Despite being located in an otherwise arid region, its extremely high elevation (; one of the highest in the U. S .) allows for a relatively mild summer that makes it a popular tourist attraction in West Texas and New Mexico.

Despite its inherent association with extremely flammable substances and objects with a pointed tip traveling at high speeds, model rocketry historically has proven to be a very safe hobby and has been credited as a significant source of inspiration for children who eventually become scientists and engineers.

Despite its low rainfall, extreme summer temperatures are marginally more moderate than nearby extremely wet towns like Forks, owing to the coastal fog.

Despite his contributions to the defeat of Napoleon and restoration of peace, Castlereagh became extremely unpopular at home.

Despite the paradise, he soon grows extremely bored ; " bored to tears ", with being the last person on Earth.

Despite his initial reluctance to take part in the competition, Ataru becomes extremely interested in the game when he meets Lum.

Despite ricin's extreme toxicity and utility as an agent of chemical / biological warfare, it is extremely difficult to limit the production of the toxin.

( Despite its aristocratic French roots, Creole cuisine does not include Garde Manger or other extremely lavish styles of the Classical Paris cuisine.