Despite extensive attempts to obtain highly pure reagents, serious difficulty was experienced in obtaining reproducible rates of reaction.

Despite serious terrain obstacles, almost three-quarters of all cross-border dry cargo is now transported by road, 105, 251 metric tons in 2005.

Despite its many ( serious ) limitations, including extremely low volume, it has considerable expressive power, the player being able to control attack, duration, volume, and even provide certain subtle effects of swelling of tone and a type of vibrato unique to the clavichord.

Despite the fact that Parsons only contributed two new songs to the album (" In My Hour of Darkness ", " Return of the Grievous Angel "), Parsons was highly enthused with his new sound and seemed to have finally adopted a serious, diligent mindset to his musical career, eschewing most drugs and alcohol during the sessions.

Despite its unpleasantness and expense, a diagnostic fast may be the only effective way to confirm or refute a number of serious forms of hypoglycemia, especially those involving excessive insulin.

Despite the arrival of serious competitors — namely, the Ford Falcon, Chrysler Valiant, and Japanese cars — in the 1960s, Holden's locally produced large six-and eight-cylinder cars remained Australia's top-selling vehicles.

Despite his reputation as a serious composer of large, complex musical structures, some of Brahms's most widely known and most commercially successful compositions during his life were small-scale works of popular intent aimed at the thriving contemporary market for domestic music-making ; indeed, during the 20th century, the influential American critic B. H. Haggin, rejecting more mainstream views, argued in his various guides to recorded music that Brahms was at his best in such works and much less successful in larger forms.

Despite a serious injury which ruled Shearer out for half the season, Dalglish achieved fourth position with the team in the first year of the new Premier League.

Despite serious domestic turmoil, the patriotism engendered by Morocco ’ s participation in the Middle East conflict and by the events in Western Sahara contributed to Hassan ’ s popularity and strengthened his hand politically.

Despite these hindrances, his aim ( and that of his collaborator John Dryden ) was to establish serious opera in England, but these hopes ended with Purcell's early death at the age of 36.

Despite the economy's general expansion after 1983, however, inflation threatened its modest gains, as did serious fiscal and balance-of-payments deficits and the growing debt.

Despite the official government statement that allowed for freedom of the press, this was the first trial of whether or not Dubcek was serious about reforms.

Despite these serious negative effects the measure was deemed necessary as tax revenue from provinces occupied and threatened by rebels had ceased to reach the cash-strapped central government.

Despite this apparent success the underlying problems remained unresolved and had already resulted in the death or serious injury of 30, 000 civilians.

Despite suffering from a serious flare-up of his chronic colitis, Lawrence decided to go, but he became ill while in Geneva, and was rushed to the hospital at Stanford University.

Despite the disdain of sousaphones held by most serious tuba players, a quality modern sousaphone is often a better choice for the high school or semi-pro player due to more stable intonation and less breath effort needed to generate tone.

Despite the continuation of single party politics ( known in this case as the Era of Good Feelings ), serious issues emerged during the election in 1820.

Despite serious cash flow problems, they moved UPI's headquarters from New York City to Washington DC, incurring additional major costs due to construction cost overruns.

Despite his occasional ( if serious ) political setbacks — usually at the hands of his great Machiavellian rival, Louis XI of France — Edward was a popular and very able king.

" Despite a serious preservation effort, The Museum of Arts & Design radically altered the building, which reopened in 2008.

Despite all these notable successes in diagnostics and detection techniques ectopic pregnancy remains a source of serious maternal morbidity and mortality worldwide, especially in countries with poor prenatal care.

Despite an arrest record dating back to the 1920s, Bonanno was never convicted of a serious crime.

Despite undoubted successes, Boleslaus III Wrymouth committed serious political errors, even against Zbigniew of Poland, his half-brother.

Despite a serious mutiny in 588, the army managed to continue the war and even secure a major victory before Martyropolis.

Despite serious initial problems with the Austrian censors who had control over northern Italian theatres at the time, the opera had a triumphant premiere and is considered by many to be the first of the operatic masterpieces of Verdi's middle-to-late career.

Despite public or media opinion, national studies have indicated that severe mental illness does not independently predict future violent behavior, on average, and is not a leading cause of violence in society.

Despite a widespread tendency to romanticize his ill health, modern critics see an artist deeply frustrated by the inactivity and incoherence brought about by his bouts of illness.

Despite his illness, Jardine was still very active in keeping an eye on business, politics and current affairs.

Despite his illness Morphy triumphed easily, winning seven while losing two, with two draws.

Despite his illness, Kirk refused to reduce his workload by any significant degree.

Despite the fact that he had been in ill health since 1991, which was speculated by the public to be from stomach cancer, to diverticulitis, to other rare ailments, the underlying and unifying cause of his illness and unexpected death has never been revealed to the public.

Despite Roddy's illness for over two years, he continued to announce for The Price Is Right for as long as he was able to, up until his last hospitalization two months before his death on October 27, 2003, less than a month after his 66th birthday.

Despite his illness, he continued publishing high quality poetry.

Despite constant illness, he produced a large amount of music, including important works such as the Second ( 1980 ) and Third ( 1983 ) String Quartets and the String Trio ( 1985 ); the Faust Cantata ( 1983 ), which he later incorporated in his opera Historia von D. Johann Fausten ; the ballet Peer Gynt ( 1985 – 1987 ); the Third ( 1981 ), Fourth ( 1984 ) and Fifth ( 1988 ) Symphonies ( the last of which is also known as the Fourth Concerto Grosso ) and the Viola ( 1985 ) and 1st Cello ( 1985 – 1986 ) concertos.

Despite his illness and heavy drinking, his liver was working at 100 % capacity.

Despite his illness, Carl continued to perform during chemotherapy treatment.

Despite strong support from Shah Jahan, who had recovered enough from his illness to remain a strong factor in the struggle for supremacy, and the victory of his army led by his eldest son Sulaiman Shikoh over Shah Shuja in the battle of Bahadurpur on February 14, 1658, Dara was defeated by Aurangzeb and Murad during the Battle of Samugarh, 13 km from Agra on May 30, 1658.

Despite her illness, Bertha Pappenheim was a strong personality.

Despite his illness, the Sultan left his litter and led his forces on horseback.

Despite the fact that many are well adjusted and go on to live happy and successful lives, in Sweden, Korean and other international adoptees are highly overrepresented when it comes to suicide, suicide attempts, mental illness, substance abuse, social maladjustment, crime and other social and personal issues ( Hjern et al.

Despite his illness, Ross never missed a day of duty, and in early 1864 he was promoted to brigadier general, becoming the ninth-youngest general officer of the Confederate Army.

Despite his illness, Arthur was a distinguished academic and a most prolific author.

Despite illness, Darwin pressed on with writing the " abstract " of his " big book " on Natural Selection ; this condensed version was published in November 1859 as On the Origin of Species.

Despite her illness she soon became interested in dance.

Despite his mother's illness Welsh arranged boxing matches in Britain, his first was against Seaman Arthur Hayes, a six round match held at the National Sporting Club in London.

Despite claiming to have an appendix full of references demonstrating that there is no evidence that medications have a role in curing mental illness, the book simply relies on a core group of antiestablishment authors.

Despite his illness, Konstantin tried to amuse himself as best he could.

Despite continued illness he was foremost in all the labours of the French Benedictines of St. Maur, and was the master of many of the most illustrious among them, e. g. Mabillon.

Despite the loss of life on the journey, by the time they reached Begemder, the army was free of the illness.