Determining a representative tertiary structure for each sequence cluster is the aim of many structural genomics initiatives.

Determining the class of water damage is an important first step, and will determine the amount and type of equipment utilized to dry-down the structure:.

Determining the nature of the planet has not been straightforward ; a 2002 paper hypothesizes that the lumps are caused by a roughly Jupiter-mass planet on an eccentric orbit.

Determining what average input means is difficult, and often that average input has properties which make it difficult to characterise mathematically ( consider, for instance, algorithms that are designed to operate on strings of text ).

Determining exactly the various influences is, after more than two thousand years of internal and external influences and developments, impossible but the result has been a large number of unique musical traditions.

Determining whether an employee has custody or possession can be difficult.

Determining ownership in law involves determining who has certain rights and duties over the property.

Determining the date of a heliacal rise of Sothis has been shown to be difficult, especially considering the need to know the exact latitude of the observation.

* Determining that the Seifert-Weber 3-manifold contains no incompressible surface has been algorithmically implemented by Rubinstein, Tillmann and Burton and based on normal surface theory.

Determining that a risk has been reduced to ALARP involves an assessment of the risk to be avoided, of the sacrifice ( in money, time and trouble ) involved in taking measures to avoid that risk, and a comparison of the two.

Determining the exact cause of CNH has proven to be difficult, specifically because only 21 additional cases have been reported since Plum and Swanson ’ s initial report of the condition in 1959.

Determining which goods have been sold, and the cost of those goods, requires either identifying the goods or using a convention to assume which goods were sold.

Determining whether any changes have been made to a message ( or a file ), for example, can be accomplished by comparing message digests calculated before, and after, transmission ( or any other event ).

Determining styles in capoeira is a very tough task, since there was never a unity in the original capoeira, or a teaching method before the decade of 1920.

Determining the date and length of Eric's reign ( before and after his father's death ) is a challenging and perhaps impossible task based on the confused chronology of our late sources.

Determining the precise end of the Republic is a task of dispute by modern historians ; Roman citizens of the time did not recognize that the Republic had ceased to exist.

Determining how written text is spoken is a hugely challenging task in itself.

Determining a precise value for a particular knot is difficult because many factors can affect a knot efficiency test: the type of fiber, the style of rope, the size of rope, whether it is wet or dry, how the knot is dressed before loading, how rapidly it is loaded, whether the knot is repeatedly loaded, and so on.

Determining the number of films he made during the early part of his career is difficult because the ad copy rarely named him.

" Although a Human Effects Advisory Panel was established in 1998 to provide independent assessment on human effects, data, and models for the use of ' non-lethal weapons ' on the general population, the TECOM Technology Symposium in 1997 concluded on non-lethal weapons: " Determining the target effects on personnel is the greatest challenge to the testing community ," primarily because " the potential of injury and death severely limits human tests.

" Determining the link between data breaches and identity theft is challenging, primarily because identity theft victims often do not know how their personal information was obtained ," and identity theft is not always detectable by the individual victims, according to a report done for the FTC.

Determining a property or site location based upon Magnetic North will result in inaccuracies because true magnetic north fluctuates.

Determining whether news is " good " or " bad " must be determined by the price action of the stock, because the market reaction may not match the tone of the news itself.

The color, consistency, acidity, and other characteristics of the discharge may be predictive of the causative agent. Determining the agent is especially important because women may have more than one infection, or have symptoms that overlap those of another infection, which dictates different treatment processes to cure the infection.

Determining which amino acid forms the N-terminus of a peptide chain is useful for two reasons: to aid the ordering of individual peptide fragments ' sequences into a whole chain, and because the first round of Edman degradation is often contaminated by impurities and therefore does not give an accurate determination of the N-terminal amino acid.

Determining mass is even more difficult, because little evidence of soft tissues survives in the fossil record.

Determining the optimal parameters in a model of this type is not trivial, and local numerical optimization methods such as gradient descent can be sensitive to initialization because of the presence of local minima of the training criterion.

Determining the appropriate treatment for noncyclical breast pain is more difficult, not only because it is hard to pinpoint where the pain is coming from, but also because the pain may not have hormonal causes and very often does not respond to hormonal treatment.

Determining the new territory too large to administer as one unit, Britain divided its new southeastern acquisitions into two new colonies separated by the Apalachicola River: East Florida, with its capital in the old Spanish city of St. Augustine, and West Florida, with its capital at Pensacola.

Determining that a sequence is functional should be distinguished from determining the function of the gene or its product.

Determining that they need a symbol of equally-powerful positivity to break through the slime, the Ghostbusters use positively-charged mood slime from their slime blowers, an adapted NES Advantage Controller, and a remix of " Higher and Higher " to animate the Statue of Liberty and pilot it through the streets of New York, using its torch to break through the museum's ceiling to attack Vigo and Janosz.

Determining appetite for operational risk is a discipline which is still in its infancy.

Determining the substance ingested is often complicated by the body's natural processes ( see ADME ), as it is rare for a chemical to remain in its original form once in the body.

Determining the composition of the Memorial depends on the dates of Nehemiah's mission: It is commonly accepted that " Artaxerxes " was Artaxerxes I ( there were two later kings of the same name ), and that Nehemiah's first period in Jerusalem was therefore 445-433 BC ; allowing for his return to Susa and second journey to Jerusalem, the end of the 5th century BC is therefore the earliest possible date for the Memorial.

Determining the satisfiability of a formula in which each clause is a Horn clause ( i. e. it contains at most one positive literal ) is P-complete ; this problem is called Horn-satisfiability.

Determining an instance of the membership problem ; i. e. given a string, determine whether where is the language generated by some grammar ; is also known as parsing.

Determining how much insurance to get, at the most cost effective terms requires knowledge of the market for personal insurance.

Determining a " country of origin " is thus much more difficult than determining other aspects of a gem ( such as cut, clarity etc.

Determining the presence of both parts of this definition is not always straightforward, as hypoglycemic symptoms and effects are vague and can be produced by other conditions ; people with recurrently low glucose levels can lose their threshold symptoms so that severe neuroglycopenic impairment can occur without much warning, and many measurement methods ( especially glucose meters ) are imprecise at low levels.

* Determining the water balance of a region.

* Determining the agricultural water balance.

Determining how many people died in these massacres overall is difficult.

Determining whether a particular event or proceeding constitutes the commencement of adversarial criminal proceedings requires both an examination of the rules of criminal procedure for the jurisdiction in which the crime is charged and the Supreme Courts cases dealing with the issue of when formal prosecution begins.

* Leading / directing: Determining what needs to be done in a situation and getting people to do it.

Determining the distances to astronomical objects is crucial to understanding them, but the vast majority of objects are too far away for their distances to be directly determined.

Determining if the customer is likely to return to reclaim an item is a subjective decision, and wily customers may attempt to persuade the pawnshop owner that the item in question is important to them (" that necklace belonged to my grandmother, so I will certainly return for it "), and they will claim that they will return to recover it.

Determining the redshift of an object in this way requires a frequency-or wavelength-range.

Determining what exactly separates a short story from longer fictional formats is problematic.

Determining the sequence is therefore useful in fundamental research into why and how organisms live, as well as in applied subjects.

Determining part of a protein's amino-acid sequence ( often one end ) by one of the above methods may be sufficient to enable the identification of a clone carrying the gene.

* Determining and prioritizing security needs and aligning them with the perceived threats and the available budget.

Determining the temperature of a pot of hot liquid required the user to leave the thermometer in the hot liquid until after reading it.