Upon exiting the endoplasmic reticulum and entering the Golgi apparatus via vesicular transport, a specific lysosomal tag, mannose 6-phosphate, is added to the peptides.

Upon entering the game, Bledsoe quickly moved the Patriots down the field and threw an 11-yard touchdown pass to David Patten to give the Patriots a 14 – 3 halftime lead.

Upon entering all service all three V bombers were initially painted in an overall silver finish, with the prominent under-nose H2S radomes on the Valiant and Vulcan left in black, however, this silver finish was later changed to one of anti-flash white, the RAF roundels being adjusted in shade, and made paler, to minimise the absorption of energy from the flash of detonating nuclear weapons.

Upon entering this coalition, Pitt said to Devonshire: " My Lord, I am sure I can save this country, and no one else can ".

Upon entering the CTV, astronauts could take off their launch and re-entry suits then proceed to chairs and beds for medical checks before being transported back to the crew quarters in the Operations and Checkout Building.

Upon entering higher education James worked as a school janitor, bellringer, carpenter, teacher, and preacher to help finance his education.

Upon both of them entering and tying for first place in a scientific contest at the University of Paris, Johann, unable to bear the " shame " of being compared as Daniel's equal, banned Daniel from his house.

Upon entering the Ying Wa College, new students are divided into five houses.

Upon entering the government, Allende relinquished his parliamentary seat for Valparaíso, which he had won in 1937.

Upon entering office in June 1970, Heath immediately set about trying to reverse Wilson's policy of ending Britain's military presence East of Suez.

Upon their arrival at Columbine, the duo met near Harris's car and armed two 20 pound ( 9 kg ) propane bombs before entering the cafeteria a few minutes prior to the beginning of the A lunch shift, placing the duffel bags containing the bombs inside.

Upon entering Oradour-sur-Glane, Sturmbannführer Diekmann had received orders from his regimental commander, Standartenführer Stadler, to only have the mayor of the town name thirty people who could serve as hostages in exchange for Sturmbannführer Kämpfe ; however, Diekmann instead ordered the population exterminated and the village burned to the ground.

Upon entering the US Open as the defending champion that year, he caused controversy when, after losing in the quarterfinals to Jim Courier, Sampras said that he was not disappointed and felt relieved that the pressure to defend his title was no longer on him.

) Upon entering office, President Woodrow Wilson segregated the United States Navy.

Upon entering his third season as Pistons coach, Saunders became the longest-tenured Pistons coach since Chuck Daly's nine-year tenure ( 1983 – 92 ).

Upon entering Nootka Sound, they found William Douglas and his ship the Iphigenia.

Upon entering the service of the Church he was placed at the head of the Catechetical School of Alexandria, where he lived and worked.

Upon entering either mode, the player will be able to select a course, find out which fruit will be the Lucky Fruit, and choose a Yoshi of desired colour to play as.

Upon entering Red Bank, County Route 520, along with County Route 11, head north on Broad Street and Route 35 heads northwest on two-lane Maple Avenue, which turns north and passes by numerous homes.

Upon entering Rahway, Route 35 crosses under the Northeast Corridor rail line just before ending at Route 27.

Upon entering the town of Blairsville, Georgia, one can see a plaque crediting John Thomas ( former Justice of the Inferior Court and serving Union County in the Georgia House of Representatives in 1833 ) for giving the county the name of Union.

Upon entering Paramus, Route 4 has a cloverleaf interchange with County Route 62 ( Paramus Road / Passaic Street ).

Upon entering Folsom, the route passes over a Conrail Shared Assets Operations railroad line before coming to a cloverleaf interchange with US 322 ( Black Horse Pike ).

( Upon entering 6th grade, all students attend Peacock Jr. High ( Currently Peacock Middle School ) on the town's North Side.

Upon entering Salem at approximately 9 a. m., Morgan immediately took possession of the town and placed guards over the stores and streets.

Upon being appointed Prime Minister of Italy, Mussolini had to form a coalition government, because the Fascists did not have control over the Italian parliament.

Upon the Ottomans ' return in 1478, a large number of Albanians fled to Italy, Greece and Egypt and maintained their Arbëresh identity.

Upon the Polos ' return to Italy, Venice was at war with Genoa.

Upon hearing of the French invasion, Otto II ’ s mother Adelaide of Italy, who was Lothair's mother-in-law, sided with Lothair over his own son and moved to the court of her brother King Conrad at Bourgogne.

Upon arriving in Italy in 981, Otto II immediately imposed a trade embargo against the island republic.

Upon his return to Italy in 1771, Zuccarelli was soon afterward elected President of the Venetian Academy.

Upon fleeing Germany, he traveled in Italy.

Upon the death of Louis II of Italy in 875, Carloman also became king of Italy and aimed at gaining the Imperial crown, but in 879, he was crippled by a stroke and divided his dominions as his father had done.

Upon his return to France, he as appointed as the Director of the Ecole Polytechnique, but early in 1798 he was sent to Italy on a mission that ended in the establishment, of the short-lived Roman Republic.

Upon learning of the invasion, the Magister militum Flavius Aëtius moved quickly from Italy into Gaul.

Upon returning to Italy, Toscanini set out on a dual path for some time.

Upon his return from Italy he Latinised his surname, an action which although self aggrandising, was somewhat fashionable at the time.

Upon her return to Italy, after having promoted her new released record in Puerto Rico, the couple suffered carbon monoxide poisoning caused by a defective heater in their apartment.

Upon the defeat of Nazi Germany ( Italy having already surrendered ), celebrations erupted throughout the Western world.

Upon his graduation from Howard University in 1941, he spent five years as an officer in the Army and saw combat in Italy during World War II as a member of the segregated 366th Infantry Regiment, earning a Bronze Star.

Upon graduation he was sent to Bern, Switzerland and later to Italy as a reporter for the Russian press.

Upon Jones ' death in 1652, Webb inherited a substantial fortune as well as a library of drawings and designs, many of which dated back to Jones ' influential travels to Italy.

Upon hearing of Bianca's impending visit, Haddock rushes to pack for a trip to Italy, figuring that now would be a good time to visit, because he had always avoided visiting the country precisely to avoid Bianca.

Upon his return Abbey was drafted into the military, where he served two years as a military police officer in Italy, after which he was honorably discharged.

According to Christopher Frayling, the author of Once Upon A Time in Italy: The Films of Sergio Leone, some of the sets are still there.

Upon landing in Italy, Dyer hastily made his way to Rome, where the Roman objects of antiquity and art, like he had been in Aberglasney, naturally attracted him.

Upon returning to Italy, Matteucci studied at Bologna ( 1832 ), Florence, Ravenna ( 1837 ) and Pisa.

Upon his return from Italy, Soprano re-organized his crew — Gualtieri would be a capo now that Tony was acting boss, Dante would become Tony's consigliere, and new addition Furio Giunta would be on an equal footing with Bonpensiero despite his years of long service.