The use of D. purpurea extract containing cardiac glycosides for the treatment of heart conditions was first described in the English-speaking medical literature by William Withering, in 1785, which is considered the beginning of modern therapeutics. It is used to increase cardiac contractility ( it is a positive inotrope ) and as an antiarrhythmic agent to control the heart rate, particularly in the irregular ( and often fast ) atrial fibrillation.

William Withering – like Small a physician – was already an acquaintance of Darwin, Boulton and Wedgwood when he moved from Stafford to Birmingham and became a member of the Society in 1776.

His contribution to the society was significant but short-lived: after collaborating with Withering on his Botanical Arrangement of British Plants the two quarrelled bitterly and Stokes severed his relations with the main Lunar members by 1788.

William Withering ( 17 March 1741 – 6 October 1799 ) was an English botanist, geologist, chemist, physician and the discoverer of digitalis.

William Withering analysing thermal waters in Portugal He was an enthusiastic chemist and geologist.

Withering deduced that Digitalis was the " active " ingredient in the formulation, and over the ensuing nine years he carefully tried out different preparations of various parts of the plant ( collected in different seasons ) and documented 156 cases where he had employed digitalis, and described the effects and the best-and safest-way of using it.

At least one of these cases was a patient whom Erasmus Darwin had asked Withering for his second opinion.

By 1800, Brown was firmly established amongst Irish botanists, and was corresponding with a number of British and foreign botanists, including Withering, Dickson, James Edward Smith and José Correia da Serra.

#" The Withering of the Boughs " (" I cried when the moon was murmuring to the birds :")

It was first recognized as a mineral species by William Withering in 1783, who discovered it in the Parys copper-mine in Anglesey ; the name anglesite, from this locality, was given by F. S. Beudant in 1832.

The Wetherspoon chain of real ale eateries has opened a new pub in New Street, Wellington, The William Withering, named for Dr William Withering who was born in the town and who discovered Digitalis, the heart medicine.

The abolitionist Dr William Withering was born in the town in 1741 ; he also investigated digitalis, used in the treatment of heart disease.

Extracted from the leaves, this same compound, whose clinical use was pioneered as digitalis by William Withering, is used as a medication for heart failure.

Withering criticism was the response of most experts.

It was later home to William Withering and since 1936, thanks to negotiations initiated by The Birmingham Civic Society with the owner, Calthorpe Estates, it has been the clubhouse for Edgbaston Golf Club.

* October 6-William Withering, English physician, discoverer of digitalis ( born 1741 )

Withering first learned of the use of Digitalis in " cardiac ( congestive heart failure ) from an old woman who practiced as a folk herbalist in Shropshire, who used the plant as part of a polyherbal formulation containing over 20 different ingredients to successfully treat this condition.

The botanist and physician Jonathan Stokes, who had known William Withering as a child, moved to Stourbridge and started attending Lunar Society meetings from 1783.

* October 6 – William Withering, a British physician ( b. 1741 )

* March 17 – William Withering, British physician ( d. 1799 )

* March 17-William Withering, English botanist, geologist, chemist and physician who discovered digitalis ( died 1799 )

The William Withering Chair in Medicine at the University of Birmingham Medical School is named after him, as is the medical school's annual William Withering Lecture.

A postscript at the end of the published volume of transactions containing Darwin's paper states that " Whilst the last pages of this volume were in the press, Dr Withering of Birmingham ... published a numerous collection of cases in which foxglove has been given, and frequently with good success ".

Allegorical figures from his works — “ Geharnischte Sonette ” (“ Withering Sonnets ”) and “ Weisheit des Brahmanen ” (“ Wisdom of the Brahmans ”) — are situated at the feet of the bronze Rückert.

His best-known students-many of whom continued to correspond with him during his long life-included ( in addition to Joseph Black, who became his colleague ) Benjamin Rush, a central figure in the founding of the United States of America ; John Morgan, who founded the first medical school in the American colonies ( the Medical School at the College of Philadelphia ); William Withering, the discoverer of digitalis ; Sir Gilbert Blane, medical reformer of the Royal Navy ; and John Coakley Lettsom, the philanthropist and founder of the Medical Society of London.

* Wolfe, Allan, " The Withering Away of the American Labor Party ," Rutgers University Library Journal, 31 ( 1968 ).

Despite this uncertainty, fourteen individuals have been identified as having verifiably attended Lunar Society meetings regularly over a long period during its most productive eras: these are Matthew Boulton, Erasmus Darwin, Thomas Day, Richard Lovell Edgeworth, Samuel Galton, Jr., James Keir, Joseph Priestley, William Small, Jonathan Stokes, James Watt, Josiah Wedgwood, John Whitehurst and William Withering.

Clinical pharmacology owes much of its foundation to the work of William Withering.

The story is that he noticed a person with dropsy ( swelling from congestive heart failure ) improve remarkably after taking a traditional herbal remedy ; Withering became famous for recognising that the active ingredient in the mixture came from the foxglove plant.

In 1785, Withering published An Account of the Foxglove and some of its Medical Uses, which contained reports on clinical trials and notes on digitalis's effects and toxicity.

Withering wrote two more editions of this work in 1787 and 1792, in collaboration with fellow Lunar Society member Jonathan Stokes, and after his death his son ( also William ) published four more.

Withering senior also carried out pioneering work into the identification of fungi and invented a folding pocket microscope for use on botanical field trips.

After this, Darwin and Withering became increasingly estranged, and eventually a horrendous argument broke out apparently resulting from Darwin having accused Withering of unprofessional behaviour by effectively poaching patients.

William Withering of Birmingham.

William Withering and the Foxglove.

Heidenstam was born in 1859, of a prosperous family.

Sherlock Holmes, the ancestor of all private eyes, was born during the 1890s.

Henrietta was discovering in the process of writing, as the born writer does, not merely a channel for the discharge of accumulated information but a stimulus to the development of the creative powers of observation, insight and intuition.

She was born Lilian Steichen, her parents immigrants from Luxemburg.

`` My mother read a book right after I was born and there was a Lilian in the book she loved and I became Lilian -- and eventually I became Paula ''.

By now she was sure she was going to have a baby, deciding it would be born in India or Burma that November.

He was born in Savannah, Georgia, in 1909.

About the only time the Hetman seemed excited was when one of his own pet ideas was born.

On April 10, 1904, his first child was born, a son named George after the late Senator.

Modern warfare was born in this campaign -- periscopes, camouflage, booby traps, land mines, extended order, trench raids, foxholes, armored cars, night attacks, flares, sharpshooters in trees, interlaced vines and treetops, which were the forerunners of barbed wire, trip wires to thwart a cavalry charge, which presaged the mine trap, and the general use of anesthetics.

Deppy is Despina Messinesi, a long-time member of the Vogue staff who, although born in Boston, was born there of Greek parents.

Samuel Gorton was born at Gorton, England, near the present city of Manchester, about 1592.

Whether the Fathers, who died before Christ was born of the Virgin Mary, were justified and saved only by the blood which he shed, and the death which he suffered after his incarnation??

Whether the only price of our redemption were not the death of Christ on the cross, with the rest of his sufferings and obediences, in the time of his life here, after he was born of the Virgin Mary??

In the judgment of Chief of Staff Scott it was ironic that the draft policy of a Democratic President, aimed at Germany, had to be pushed through the House of Representatives by the ranking minority member of the Military Affairs Committee -- a Republican Jew born in Germany!!

Thus, the Church was born and because of its intrinsic character was soon identified as a conservative institution, determined to resist the forces of change, to identify itself with the political rulers, and to maintain a kind of splendid isolation from the masses.

And she replied, `` I was born in America, but I was conceived in Vienna ''.

I was born angry.

He kept his attacks on Republicanism for partisan campaigns, but that is part of the game he was born to play.