By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By the 18th century an increasing number of new plants had arrived in Europe from newly discovered countries and the European colonies worldwide and a larger number of plants became available for study.

By 2007, 200 billion CDs had been sold worldwide.

By providing a worldwide, distributed keyword-based redirection service, the Domain Name System is an essential component of the functionality of the Internet.

By the 1930s, several faith healers drew large crowds and established worldwide followings.

By the time of his resignation as chairman of the board in 1989 he had transformed Heineken from a brand that was known chiefly in the Netherlands to a brand that is currently famous worldwide.

By 2005, GSM networks accounted for more than 75 % of the worldwide cellular network market, serving 1. 5 billion subscribers.

To manage the merchandise, Davis founded Paws, Inc. By 2002, Garfield became the world's most syndicated strip, appearing in 2, 570 newspapers with 263 million readers worldwide ; by 2004, Garfield appeared in nearly 2, 600 newspapers and sold from $ 750 million to $ 1 billion worth of merchandise in 111 countries.

By the 21st century, an estimated 80 million people worldwide claim some Irish descent ; among them are 41 million Americans who claim " Irish " as their primary ethnicity.

By age 15, he had already given concerts worldwide.

By October 1918, it had spread to become a worldwide pandemic on all continents, and eventually infected about one-third of the world's population ( or ≈ 500 million persons ).

By the late 1990s, the message board forum at the site had developed into a thriving community with a large number of regular members and contributors worldwide.

By 1992, more than 300 births had occurred in captivity, and more than 300 individuals lived in 85 institutions worldwide.

By the end of 2009, there were a total of nearly 6 billion mobile and fixed-line subscribers worldwide.

By the Academic Ranking of World Universities, one of its campuses, UC Berkeley, is ranked second worldwide among public and private universities, and three — Berkeley, Los Angeles, and San Diego — are ranked among the top 15.

By 2010, same-sex marriage was legal and performed in 10 countries worldwide, although only in some jurisdictions in Mexico and the United States.

By June 20, 2010, Aniston's movies had grossed more than $ 1 billion in the United States and over $ 1. 7 billion worldwide.

By the year 2000, there were enough civilian and government organizations worldwide using ALE that it became a de facto HF interoperability standard for situations where a priori channel and address coordination is possible.

Bob Marley in France noted as a Rasta. By 1997, there were, according to one estimate, around one million Rastafari faithful worldwide.

By the late 2000s, TM had been taught to millions of people, and the worldwide TM organization had grown to include educational programs, health products, and related services.

By the time this group became extinct about 220 million years ago, they had spread worldwide.

By focussing on just a few of these highly variable minisatellites, DNA profiling made the system more sensitive, more reproducible, and amenable to computer databasing, and soon became the standard forensic DNA system used in criminal case work and paternity testing worldwide.

By 2000, Hughes Space and Communications ( now Boeing Satellite Development Center ) had built nearly 40 percent of the more than one hundred satellites in service worldwide.

By the end of the war the worldwide strength of the Fleet Air Arm was 59 aircraft carriers, 3, 700 aircraft, 72, 000 officers and men, and 56 Naval air stations.

By 1992, Disintegration had sold over three million copies worldwide.