By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

Suggest the following twenty-first-century amendment: By moving the term `` Republic '' to lower case, substituting the modern phrase, `` move ahead '' for the stodgy `` keep '', and by using the Postmaster's name on every envelope ( in caps, of course, with the `` in spite '' as faded as possible ), the slogan cannot fail.

By now few Angolans retain African traditional religions following different ethnic faiths.

By 1865, following the American Civil War, stocks in small industrial companies, such as iron and steel, textiles and chemicals were first sold by curbstone brokers.

By his marriage with Irene Doukaina, Alexios I had the following children:

By the 1850s when they first came into sustained contact by outside groups, there were estimated 7, 000 Adamanese, divided into the following major groups:

By his mistress Theodora Komnene, Andronikos I had the following issue:

By the 19th century orchestral music in Europe had standardized the string section into the following homogeneous instrumental groups: first violins, second violins, violas, cellos, and double basses.

By March 756, Abd al-Rahman and his growing following of Umayyad clients and Yemenite junds, were able to take Sevilla without violence.

By the following year their ranks had grown to include German painter, sculptor and designer Oskar Schlemmer who headed the theater workshop, and Swiss painter Paul Klee, joined in 1922 by Russian painter Wassily Kandinsky.

By March 1918, when the organization came to Moscow, it contained the following sections: against counterrevolution, speculation, non-residents, and information gathering.

By 1921, it changed once again, forming the following sections: directory of affairs, administrative-organizational, secretly operative, economical, and foreign affairs.

By December 2001, it was ratified by the ECMA, with ISO standardization following in April 2003.

By 1935, the company had established a true production line, following the example of Ford, and were producing a car closely resembling the Austin 7.

By mid century, the cooperative Christian Churches and the independent Christian Churches were following different paths.

" By the end of the following year he had taken up the ukelele and tea-chest bass and begun to participate in skiffle sessions with friends, and had started to play the piano ; meanwhile his stage presentation of numbers by both Presley and Chuck Berry — complete with gyrations in tribute to the original artists — to his local Wolf Cub group was described as " mesmerizing ... like someone from another planet.

By 1987, with Yzerman, now the captain following the departure of Danny Gare, joined by Petr Klima, Adam Oates, Gerard Gallant, defenseman Darren Veitch and new head coach Jacques Demers, the Wings won a playoff series for only the second time in the modern era.

By 1951, 87 subroutines in the following categories were available for general use: floating point arithmetic ; arithmetic operations on complex numbers ; checking ; division ; exponentiation ; routines relating to functions ; differential equations ; special functions ; power series ; logarithms ; miscellaneous ; print and layout ; quadrature ; read ( input ); nth root ; trigonometric functions ; counting operations ( simulating repeat until loops, while loops and for loops ); vectors ; and matrices.

By birthplace one can derive the following origins of the inhabitants: born on the Faroes 91. 7 %, in Denmark 5. 8 %, and in Greenland 0. 3 %.

By the time of the conquest, the island was divided into two Guanches kingdoms, one following the king Guize and the other Ayoze.

By autumn 1917, in the power vacuum following the dissolution of parliament and in the absence of a stable government or a Finnish army, such forces began assuming a more military character.

By the end of 1968 there were at least 1, 300 Moroccan workers resident in Gibraltar and this more than doubled following the final closure of the frontier with Spain in June 1969.

By this time, however, trade with the European continent had spread this outbreak of plague to France, where it died out the following winter.

By 1968 Parsons had come to the attention of The Byrds ' bassist, Chris Hillman, via Larry Spector ( The Byrds ' business manager ), as a possible replacement band member following the departures of David Crosby and Michael Clarke from the group in late 1967.

By spring 1941, following Himmler's orders, ten concentration camps had been constructed in which inmates were subjected to forced labour.

By the reign of Alexander III, the Scots were in a position to annexe the remainder of the western seaboard, which they did following Haakon Haakonarson's ill-fated invasion and the stalemate of the Battle of Largs with the Treaty of Perth in 1266.