By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By 1971, all the divisions of Indiana Standard bore the Amoco name including American Oil which was renamed Amoco Oil with American stations renamed Amoco stations.

By 1975, Amoco began phasing in the Amoco name in the old Indiana Standard sales territory.

By the late 1960s, Humble officials realized that the time had come to develop a new brand name that could be used nationwide.

By the time of his resignation as chairman of the board in 1989 he had transformed Heineken from a brand that was known chiefly in the Netherlands to a brand that is currently famous worldwide.

By age nine he was growing, grinding, bottling and selling his own brand of horseradish sauce, based on his mother's recipe.

By writing his comedies in a combination of Elizabethan and Plautine styles, Shakespeare helps to create his own brand of comedy, one that uses both styles.

By the twentieth century, the modern notion of science as a special brand of information about the world, practiced by a distinct group and pursued through a unique method, was essentially in place.

By January 2005, Vestel and its rival Turkish electronics and white goods brand Beko accounted for more than half of all TV sets manufactured in Europe.

By unifying its network of funeral homes and cemeteries under one brand name, SCI believed it could establish recognizable and communicable brand values.

By far the most recognizable brand was their Crayola “ Gold Medal ” line in the familiar yellow boxes.

By the late 1980s buyers began to regard PCs as commodities, and doubted that the security blanket of the IBM brand warranted the greater price.

By this time, Olds had displaced Pontiac and Plymouth as the # 3 best-selling brand in the U. S. behind Chevrolet and Ford.

By this point, Cadbury was the brand leader in the United Kingdom.

By December 2002, EasyJet and Go operated under one Air Operators Certificate ( AOC ) and in April 2003 the airlines operated as one, fully under the EasyJet brand.

By associating the drink's image with these activities, the company seeks to promote a " cool " public image and raise brand power.

By April 2009 several automotive websites and business publications were reporting that GM was doing a study suggesting it might eliminate the brand altogether, along with sister truck brand GMC.

By building new district as het Loo and Isseldoks, and the opening of a brand new theatre and cinema, Doetinchem is the biggest growing city in Gelderland.

By 1968, Matchbox was the biggest-selling brand of small diecast model cars worldwide.

By 1982 it was the highest selling Courage brand and the highest selling canned bitter in the United Kingdom.

By the time he died in 1844, 77, 000 copies of his fables had been sold in Russia, and his unique brand of wisdom and humor gained popularity.

By 1988, parent company Pillsbury had relaxed many of Smith's changes, scaled back on the construction of new locations which resulted in stalled growth of the brand.

By 1989 Vauxhall was on roughly equal terms with the Rover Group as Britain's second most popular car brand ( after Ford ).

By 2009, Kia was firmly established as a popular brand in Britain, when sales broke the 50, 000 barrier for the first time and the brand now had a share of more than 2 % in the new car market.