Upon receptor activation, the intracellular receptor domain activates the GTPase, which in turn activates other molecules of the signal transduction chain, either via the α unit or the βγ complex.

Upon activation, a proto-oncogene ( or its product ) becomes a tumor-inducing agent, an oncogene.

Upon activation, they assign proteins to specific membrane subdomains where they participate in signaling.

Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A.

Upon activation, K. I. Sawyer was placed under the Jurisdiction of Air Defense Command ( ADC ) on 8 April 1956.

Upon activation the normal traffic light cycle is suspended and replaced by the " preemption sequence ": the traffic lights to all approaches to the intersection are switched to " red " with the exception of the light for the vehicle that has triggered the preemption sequence.

Upon activation, the 66th, 414th and 433d Fighter Weapons Squadrons were inactivated, becoming the " A-10 ", " F-4E " and " F-15A " Divisions of the FWS.

Upon activation, TF binds with coagulation factors which then triggers the extrinsic pathway ( via Factor VII ) which subsequently triggers the intrinsic pathway ( XII to XI to IX ) of coagulation.

Upon activation, they marginate ( position themselves adjacent to the blood vessel endothelium ), and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into tissues, where they survive for 1 – 2 days.

Upon activation, it tells Sarah that it is a gift from the Doctor.

Upon activation, ERK may phosphorylate a number of cytoplasmic and nuclear molecules that ultimately result in the protein synthesis and morphological changes observed in L-LTP.

Upon activation of the spoiler, a high pressure zone is created in front of the flap, and this high pressure zone is exploited — two air intakes are revealed upon application that will allow the high pressure airflow to enter ducts that route air to aid in cooling the rear brakes.

Upon activation, AMPK increases cellular energy levels by inhibiting anabolic energy consuming pathways ( fatty acid synthesis, protein synthesis, etc.

Upon activation by thrombin, ( factor IIa ), it dissociates from the complex to interact with factor IXa in the coagulation cascade.

Upon activation, " low-affinity " IL-2 receptors are replaced by " high-affinity " IL-2 receptors consisting of α, β, and γ chains.

Upon activation by its ligand agrin, MuSK signals via two proteins called " Dok-7 " and " rapsyn ", to induce " clustering " of acetylcholine receptors ( AChR ).

Upon being called up, service members will usually be screened for their medical and personal status in order to qualify or disqualify them for activation.

Upon activation, operational units of the wing were the 367th, 368th and 369th Bombardment Squadrons under the 306th Bombardment Group which was transferred from the 307th BMW.

Upon activation, area code 954 had the distinction of being the only area code within Florida to encompass only one county.

Upon activation, data loggers are typically deployed and left unattended to measure and record information for the duration of the monitoring period.

Upon activation by PDGF, these receptors dimerise, and are " switched on " by auto-phosphorylation of several sites on their cytosolic domains, which serve to mediate binding of cofactors and subsequently activate signal transduction, for example, through the PI3K pathway.

Upon the binding of C1 to immune complexes by virtue of the affinity of C1q for immunoglobulins ( to be specific, IgM and IgG ), the controlling action of C1-In is overcome, and C1q effects activation of C1r2s2.

Upon activation, protein kinase C enzymes are translocated to the plasma membrane by RACK proteins ( membrane-bound receptor for activated protein kinase C proteins ).

Upon activation at Shaw, the 20th FW assumed the personnel and equipment of the inactivated 363d Fighter Wing.

Upon second thought we were forced to realize that we have very few reliable historical benchmarks against which we might compare the present situation, and that conclusions that present-day students are `` more '' or `` less '' religious could not be defended on the basis of our data.

Upon the American INvasion of Puerto Rico, 10 US dollars were needed to buy 1 Puerto Rican peso.

Upon a desert island were eventually cast.

Upon arriving at the rim of North Ray Crater, they were away from the LM.

IQ and cognition were unaffected, but declarative memory deficits were observed ( although not to the extent of that seen in Patient H. M .) Upon death, an autopsy revealed that Patient R. B.

Upon their deaths, his infant son, and niece, Julia Flavia, were likewise enrolled among the gods.

Roger Ebert approves of the use of the label in unsuccessful films that had been tampered with by studio executives, such as Sergio Leone's original cut of Once Upon a Time in America, and the moderately successful theatrical version of Daredevil, which were altered by studio interference for their theatrical release.

Upon further examination, it was concluded that if the marks were bite marks, they did not match the teeth of any of the three convicted.

Upon presenting the painting to the convention, he said " Citizens, the people were again calling for their friend ; their desolate voice was heard: David, take up your brushes .., avenge Marat ...

Upon his death, Headrick was cremated, and, as requested by him, his ashes were molded into memorial Frisbees and given to family and close friends.

The most popular Spaghetti Westerns were those of Sergio Leone, whose Dollars Trilogy ( A Fistful of Dollars, For a Few Dollars More, and The Good, the Bad and the Ugly ), featuring Clint Eastwood and scores by Ennio Morricone, came to define the genre along with Once Upon a Time in the West.

Upon the flight's landing, he was questioned by police, but no charges were filed.

Upon his death Ansbach and Kulmbach were inherited by younger princes of the Brandenburg line according to the House Treaty of Gera of 1598.

Abraham Foxman of the Anti-Defamation League announced: " Upon reflection, the consequences of those actions were indeed tantamount to genocide ".

Upon his return to the astronaut corps in Houston, he played a key role in training Apollo crews to be geologic observers when they were in lunar orbit and competent geologic field workers when they were on the lunar surface.

Upon taking Mazar-i-Sharif in 1998, about 4, 000 civilians were executed by the Taliban and many more reported tortured.

Upon his death on 21 September 1440, his territories were divided between his sons:

Upon Babur's death, Humayun's territories were the least secure.

In his Essay Upon Several Subjects Concerning British Antiquities, written just after the Jacobite rising of 1745 he described how the politics of Scotland were not based on loyalty to Kings or Queens as Jacobites had said but on royal land grants given in return for loyalty.

Upon her death, the rights were passed to her son, who retains them.

Upon the Colts arrival in Indianapolis over 143, 000 requests for season tickets were received in just two weeks.

Upon their return home, the Jags were greeted by an estimated 40, 000 fans at the stadium.

Upon the death of Volkel in 1828, the brothers expected to be advanced to the first and second librarianships respectively, and were dissatisfied when the first place was given to Rommel, the keeper of the archives.