Upon receptor activation, the intracellular receptor domain activates the GTPase, which in turn activates other molecules of the signal transduction chain, either via the α unit or the βγ complex.

Upon activation, a proto-oncogene ( or its product ) becomes a tumor-inducing agent, an oncogene.

Upon activation, they assign proteins to specific membrane subdomains where they participate in signaling.

Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A.

Upon activation, K. I. Sawyer was placed under the Jurisdiction of Air Defense Command ( ADC ) on 8 April 1956.

Upon activation the normal traffic light cycle is suspended and replaced by the " preemption sequence ": the traffic lights to all approaches to the intersection are switched to " red " with the exception of the light for the vehicle that has triggered the preemption sequence.

Upon activation, the 66th, 414th and 433d Fighter Weapons Squadrons were inactivated, becoming the " A-10 ", " F-4E " and " F-15A " Divisions of the FWS.

Upon activation, TF binds with coagulation factors which then triggers the extrinsic pathway ( via Factor VII ) which subsequently triggers the intrinsic pathway ( XII to XI to IX ) of coagulation.

Upon activation, they marginate ( position themselves adjacent to the blood vessel endothelium ), and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into tissues, where they survive for 1 – 2 days.

Upon activation, it tells Sarah that it is a gift from the Doctor.

Upon activation, ERK may phosphorylate a number of cytoplasmic and nuclear molecules that ultimately result in the protein synthesis and morphological changes observed in L-LTP.

Upon activation, AMPK increases cellular energy levels by inhibiting anabolic energy consuming pathways ( fatty acid synthesis, protein synthesis, etc.

Upon activation by thrombin, ( factor IIa ), it dissociates from the complex to interact with factor IXa in the coagulation cascade.

Upon activation, " low-affinity " IL-2 receptors are replaced by " high-affinity " IL-2 receptors consisting of α, β, and γ chains.

Upon activation by its ligand agrin, MuSK signals via two proteins called " Dok-7 " and " rapsyn ", to induce " clustering " of acetylcholine receptors ( AChR ).

Upon being called up, service members will usually be screened for their medical and personal status in order to qualify or disqualify them for activation.

Upon activation, operational units of the wing were the 367th, 368th and 369th Bombardment Squadrons under the 306th Bombardment Group which was transferred from the 307th BMW.

Upon activation, area code 954 had the distinction of being the only area code within Florida to encompass only one county.

Upon activation, data loggers are typically deployed and left unattended to measure and record information for the duration of the monitoring period.

Upon activation by PDGF, these receptors dimerise, and are " switched on " by auto-phosphorylation of several sites on their cytosolic domains, which serve to mediate binding of cofactors and subsequently activate signal transduction, for example, through the PI3K pathway.

Upon the binding of C1 to immune complexes by virtue of the affinity of C1q for immunoglobulins ( to be specific, IgM and IgG ), the controlling action of C1-In is overcome, and C1q effects activation of C1r2s2.

Upon activation, protein kinase C enzymes are translocated to the plasma membrane by RACK proteins ( membrane-bound receptor for activated protein kinase C proteins ).

Upon activation at Shaw, the 20th FW assumed the personnel and equipment of the inactivated 363d Fighter Wing.

Upon activation, Kinross-based interceptors were directed to intercept unknown aircraft by ADC surveillance Radars at Sault Sainte Marie AFS ( P-86 ); Grand Marais AFS ( M-109 ); Calumet AFS ( P-16 ); Alpena AFS ( M-105 ) and Empire AFS ( P-34 ).

Upon the death of Louis XIV and the abandonment of Versailles, the Paris high society became the purveyors of style.

Upon learning of the outcome of the battle of Yenidje, the Bulgarian high command urgently dispatched their 7th Rila Division from the north in the direction of the city.

Upon graduating from high school he joined the Israel Defense Forces in 1966 and served in the Paratroopers Brigade.

Upon the request of a high official named Sporacius, Theodoret compiled a Compendium of Heretical Accounts ( Haereticarum fabularum compendium ), including a heresiology ( books i-iv ) and a " compendium of divine dogmas " ( book v ), which, apart from Origen's De principiis and the theological work of John of Damascus, is the only systematic representation of the theology of the Greek Fathers.

Upon meeting him for an interview on international politics which lasts over the course of a night, she realizes that writing has been her only escape from her frustrated high society existence.

Forest rangers kept the curious well back from the fallen debris until Army personnel arrived, Upon examination, it was found to be a Japanese bombing balloon with four incendiary bombs and one high explosive bomb still aboard and the bomb releasing mechanism still very much intact.

" Upon speaking with his supervisor, Lazar claims he was informed that the aircraft was indeed an " Aurora ," a " high altitude research plane.

Upon his graduation from high school, Rose signed a professional contract.

" Upon the Mother depend the winds, the ocean, the whole earth beneath the snowy seat of Olympus ; whenever she leaves the mountains and climbs to the great vault of heaven, Zeus himself, the son of Cronus, makes way, and all the other immortal gods likewise make way for the dread goddess ," the seer Mopsus tells Jason in Argonautica ; Jason climbed to the sanctuary high on Mount Dindymon to offer sacrifice and libations to placate the goddess, so that the Argonauts might continue on their way.

Upon applying extremely high pressure ( several hundred atmospheres ) to a mixture of ethylene and benzaldehyde they again produced a white, waxy, material.

Upon his graduation from high school in June 1962, McLain was signed by the Chicago White Sox as an amateur free agent and was assigned to play with the Harlan Smokies of the Appalachian League.

Upon Graduation, most kids go onto Santa Fe High School, while some go on to either St Paul Lutheran High in Concordia, MO, or other local public high schools.

Upon graduation, the participating students receive an associate's degree along with a high school diploma.

Upon arriving at the meeting point of the Wisconsin and Pelican Rivers at the site of John Curran's trading post, and seeing the high banks along the rapids and the excellent pine stands, Anderson Brown envisioned a mill town with a lumber mill powered by the waters of the Wisconsin River.

Upon entering high school, grades 9 through 12 ( high school ) also have alternate names for students, namely Freshman, Sophomore, Junior and Senior.

Upon completion of his elementary school education in his hometown, he attended middle school and high school in Isparta and Afyon, respectively.

Upon graduation from high school, he entered Eastern Illinois University, and then transferred to Illinois State University, where he majored in theatre.

Upon his return to Japan, he assumed a high rank as a medical doctor in the Japanese army and pushed for a more scientific approach to medical research, even publishing a medical journal out of his own funds.

Upon the restoration of Charles II to the British throne in 1660, Ormonde became a major figure in English and Irish politics, holding many high government offices.

Upon graduation from high school, she started working steadily, appearing Off-Broadway in the musicals The Penny Friend ( 1966 ) and Curley McDimple ( 1967 ) and as a standby on Broadway in The Girl in the Freudian Slip ( 1967 ).

Upon exposure to blue light, all emulsions act in an additive manner to produce a high contrast image.

Upon the roof, on the outside, is the imperial, which is generally filled with six or seven persons more, and a heap of luggage, which latter also occupies the basket, and generally presents a pile, half as high again as the coach, which is secured by ropes and chains, tightened by a large iron windlass, which also constitutes another appendage of this moving mass.

Upon reaching London, news of the exotic foreigner with bizarre habits spread quickly and Psalmanazar began to achieve a high level of fame.

In his short work with E. Hoffmann Price, " Through the Gates of the Silver Key ," H. P. Lovecraft briefly mentions Tartary: " Upon their cloaked heads there now seemed to rest tall, uncertainly coloured mitres, strangely suggestive of those on certain nameless figures chiselled by a forgotten sculptor along the living cliffs of a high, forbidden mountain in Tartary ..."