Upon receptor activation, the intracellular receptor domain activates the GTPase, which in turn activates other molecules of the signal transduction chain, either via the α unit or the βγ complex.

Upon activation, a proto-oncogene ( or its product ) becomes a tumor-inducing agent, an oncogene.

Upon activation, they assign proteins to specific membrane subdomains where they participate in signaling.

Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A.

Upon activation, K. I. Sawyer was placed under the Jurisdiction of Air Defense Command ( ADC ) on 8 April 1956.

Upon activation the normal traffic light cycle is suspended and replaced by the " preemption sequence ": the traffic lights to all approaches to the intersection are switched to " red " with the exception of the light for the vehicle that has triggered the preemption sequence.

Upon activation, the 66th, 414th and 433d Fighter Weapons Squadrons were inactivated, becoming the " A-10 ", " F-4E " and " F-15A " Divisions of the FWS.

Upon activation, they marginate ( position themselves adjacent to the blood vessel endothelium ), and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into tissues, where they survive for 1 – 2 days.

Upon activation, it tells Sarah that it is a gift from the Doctor.

Upon activation, ERK may phosphorylate a number of cytoplasmic and nuclear molecules that ultimately result in the protein synthesis and morphological changes observed in L-LTP.

Upon activation of the spoiler, a high pressure zone is created in front of the flap, and this high pressure zone is exploited — two air intakes are revealed upon application that will allow the high pressure airflow to enter ducts that route air to aid in cooling the rear brakes.

Upon activation, AMPK increases cellular energy levels by inhibiting anabolic energy consuming pathways ( fatty acid synthesis, protein synthesis, etc.

Upon activation by thrombin, ( factor IIa ), it dissociates from the complex to interact with factor IXa in the coagulation cascade.

Upon activation, " low-affinity " IL-2 receptors are replaced by " high-affinity " IL-2 receptors consisting of α, β, and γ chains.

Upon activation by its ligand agrin, MuSK signals via two proteins called " Dok-7 " and " rapsyn ", to induce " clustering " of acetylcholine receptors ( AChR ).

Upon being called up, service members will usually be screened for their medical and personal status in order to qualify or disqualify them for activation.

Upon activation, operational units of the wing were the 367th, 368th and 369th Bombardment Squadrons under the 306th Bombardment Group which was transferred from the 307th BMW.

Upon activation, area code 954 had the distinction of being the only area code within Florida to encompass only one county.

Upon activation, data loggers are typically deployed and left unattended to measure and record information for the duration of the monitoring period.

Upon activation by PDGF, these receptors dimerise, and are " switched on " by auto-phosphorylation of several sites on their cytosolic domains, which serve to mediate binding of cofactors and subsequently activate signal transduction, for example, through the PI3K pathway.

Upon the binding of C1 to immune complexes by virtue of the affinity of C1q for immunoglobulins ( to be specific, IgM and IgG ), the controlling action of C1-In is overcome, and C1q effects activation of C1r2s2.

Upon activation, protein kinase C enzymes are translocated to the plasma membrane by RACK proteins ( membrane-bound receptor for activated protein kinase C proteins ).

Upon activation at Shaw, the 20th FW assumed the personnel and equipment of the inactivated 363d Fighter Wing.

Upon activation, Kinross-based interceptors were directed to intercept unknown aircraft by ADC surveillance Radars at Sault Sainte Marie AFS ( P-86 ); Grand Marais AFS ( M-109 ); Calumet AFS ( P-16 ); Alpena AFS ( M-105 ) and Empire AFS ( P-34 ).

Upon release of cytochrome c to the cytoplasm, the protein binds apoptotic protease activating factor-1 ( Apaf-1 ).

Upon release, the free actin monomer slowly dissociates from ADP, which in turn rapidly binds to the free ATP diffusing in the cytosol, thereby forming the ATP-actin monomeric units needed for further barbed-end filament elongation.

Upon release of calcium from the sarcoplasmic reticulum calcium binds to troponin C ( calcium binding troponin ).

Upon release of Ca < sup > 2 +</ sup >, the troponin complex — specifically troponin C ( TnC )— binds calcium, resulting in a conformational change of tropomyosin that physically shifts the protein on actin and fully exposes the myosin binding sites.

Upon encountering a host bacterium, the tail section of the virion binds to receptors on the cell surface and delivers the DNA into the cell by use of an injectisome-like mechanism ( an injectisome is a nanomachine that evolved for the delivery of proteins by type III secretion ).

Upon intelligence that the formidable agitator was to favor them with his presence, the benighted inhabitants of Pawtuxet, alas, gave their allegiance to Massachusetts and asked that colony to expel the newcomers.

Upon such hearing, the Commission may affirm, modify, or revise its former action with respect to such claim, including a denial or reduction in the amount theretofore allowed with respect to such claim.

Upon arriving at Baltimore, Selkirk on December 22 wrote to John Quincy Adams, Secretary of State at Washington, inquiring about laws covering trade with `` Missouri and Illinois Territories ''.

Upon which the detective bureau despatched rifle squads to prevent trouble if O'Banion should send his gunmen out to deal with the hijacking policemen.

* Upon his adoption by Caesar, he took Caesar's name and become Gaius Julius Caesar Octavianus in accordance with Roman adoption naming standards.

A Fire Upon the Deep won the Hugo Award in 1993 ( tied with Doomsday Book by Connie Willis ).

A Fire Upon the Deep shared the 1993 Hugo Award for Best Novel with Doomsday Book, by Connie Willis.

Upon Paul's arrival in Jerusalem, he was confronted with the rumor of teaching against the Law of Moses ().

Upon Gassmann's death on 22 January, most likely due to complications from an accident with a carriage some years earlier, Salieri succeeded him as assistant director of the Italian opera in early 1774.

Upon returning to Vienna following his success in Paris, Salieri met and befriended Lorenzo Da Ponte and had his first professional encounters with Mozart.

Upon his return, the Buddha says, among other things, that Pasenadi is " a friend of virtue, acquainted with virtue, intimate with virtue ", while the opposite is said of the aggressor, King Ajatasattu.

Chapter 17 of William Bates ' 1920 book Perfect Sight Without Glasses, in which the author argues that observation of the sun is beneficial to those with poor vision, includes a figure of somebody " Focussing the Rays of the Sun Upon the Eye of a Patient by Means of a Burning Glass.

Upon heating, α-berkelium transforms into another phase with an fcc lattice ( but slightly different from β-berkelium ), space group Fmm and the lattice constant of 500 pm ; this fcc structure is equivalent to the closest packing with the sequence ABC.

Upon return the air in the area was still filled with toxic smoke from the World Trade Center fires that persisted until January 2002.

Upon Jamaica's independence in 1962, the Cayman Islands broke its administrative links with Jamaica and opted to become a direct dependency of the British Crown, with the chief official of the islands being the Administrator.

A Married Women ( Restraint Upon Anticipation ) Act was passed in 1949 “ to equalise, to render inoperative any restrictions upon anticipation or alienation attached to the enjoyment of property by a woman ,” while the Married Women ( Maintenance ) Act of 1949 was enacted with the intention of improving the adequacy and duration of financial benefits for married women.

Upon the end of the meeting, Dzerzhinsky reported to the Sovnarkom with the requested information.

Upon the motion to certify the class, the defendants may object to whether the issues are appropriately handled as a class action, to whether the named plaintiffs are sufficiently representative of the class, and to their relationship with the law firm or firms handling the case.

Upon his death, he left a country doubled in size ( mostly through the addition of land in today's Ukraine, then the Duchy of Halicz ), prosperous, wealthy and with great prospects for the future.

Upon the reopening of the Warner animation department, Jones was rehired and reunited with most of his unit.

Upon his arrival back in Montreal, Thompson retired with a generous pension from the North West Company.