Upon receptor activation, the intracellular receptor domain activates the GTPase, which in turn activates other molecules of the signal transduction chain, either via the α unit or the βγ complex.

Upon activation, a proto-oncogene ( or its product ) becomes a tumor-inducing agent, an oncogene.

Upon activation, they assign proteins to specific membrane subdomains where they participate in signaling.

Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A.

Upon activation, K. I. Sawyer was placed under the Jurisdiction of Air Defense Command ( ADC ) on 8 April 1956.

Upon activation the normal traffic light cycle is suspended and replaced by the " preemption sequence ": the traffic lights to all approaches to the intersection are switched to " red " with the exception of the light for the vehicle that has triggered the preemption sequence.

Upon activation, the 66th, 414th and 433d Fighter Weapons Squadrons were inactivated, becoming the " A-10 ", " F-4E " and " F-15A " Divisions of the FWS.

Upon activation, TF binds with coagulation factors which then triggers the extrinsic pathway ( via Factor VII ) which subsequently triggers the intrinsic pathway ( XII to XI to IX ) of coagulation.

Upon activation, they marginate ( position themselves adjacent to the blood vessel endothelium ), and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into tissues, where they survive for 1 – 2 days.

Upon activation, it tells Sarah that it is a gift from the Doctor.

Upon activation, ERK may phosphorylate a number of cytoplasmic and nuclear molecules that ultimately result in the protein synthesis and morphological changes observed in L-LTP.

Upon activation of the spoiler, a high pressure zone is created in front of the flap, and this high pressure zone is exploited — two air intakes are revealed upon application that will allow the high pressure airflow to enter ducts that route air to aid in cooling the rear brakes.

Upon activation, AMPK increases cellular energy levels by inhibiting anabolic energy consuming pathways ( fatty acid synthesis, protein synthesis, etc.

Upon activation by thrombin, ( factor IIa ), it dissociates from the complex to interact with factor IXa in the coagulation cascade.

Upon activation, " low-affinity " IL-2 receptors are replaced by " high-affinity " IL-2 receptors consisting of α, β, and γ chains.

Upon being called up, service members will usually be screened for their medical and personal status in order to qualify or disqualify them for activation.

Upon activation, operational units of the wing were the 367th, 368th and 369th Bombardment Squadrons under the 306th Bombardment Group which was transferred from the 307th BMW.

Upon activation, area code 954 had the distinction of being the only area code within Florida to encompass only one county.

Upon activation, data loggers are typically deployed and left unattended to measure and record information for the duration of the monitoring period.

Upon activation by PDGF, these receptors dimerise, and are " switched on " by auto-phosphorylation of several sites on their cytosolic domains, which serve to mediate binding of cofactors and subsequently activate signal transduction, for example, through the PI3K pathway.

Upon the binding of C1 to immune complexes by virtue of the affinity of C1q for immunoglobulins ( to be specific, IgM and IgG ), the controlling action of C1-In is overcome, and C1q effects activation of C1r2s2.

Upon activation, protein kinase C enzymes are translocated to the plasma membrane by RACK proteins ( membrane-bound receptor for activated protein kinase C proteins ).

Upon activation at Shaw, the 20th FW assumed the personnel and equipment of the inactivated 363d Fighter Wing.

Upon activation, Kinross-based interceptors were directed to intercept unknown aircraft by ADC surveillance Radars at Sault Sainte Marie AFS ( P-86 ); Grand Marais AFS ( M-109 ); Calumet AFS ( P-16 ); Alpena AFS ( M-105 ) and Empire AFS ( P-34 ).

Upon the expiration of a period deemed adequate for demonstration purposes for each plant, but not to exceed such twelve-year period, the Secretary shall proceed as promptly as practicable to dispose of any plants so constructed by sale to the highest bidder, or as may otherwise be directed by Act of Congress.

Choreographed by Mr. Nagrin, the work filled the second half of a program that also offered the first New York showing of Miss Tamiris' `` Once Upon A Time '' as well as her `` Women's Song '' and Mr. Nagrin's `` Indeterminate Figure ''.

* Upon his adoption by Caesar, he took Caesar's name and become Gaius Julius Caesar Octavianus in accordance with Roman adoption naming standards.

Upon his assumption into immortality on Olympus, Heracles is given ambrosia by Athena, while the hero Tydeus is denied the same thing when the goddess discovers him eating human brains.

A Fire Upon the Deep is a science fiction novel by American writer Vernor Vinge, a space opera involving superhuman intelligences, aliens, variable physics, space battles, love, betrayal, genocide, and a conversation medium resembling Usenet.

A Fire Upon the Deep won the Hugo Award in 1993 ( tied with Doomsday Book by Connie Willis ).

A Fire Upon the Deep shared the 1993 Hugo Award for Best Novel with Doomsday Book, by Connie Willis.

Upon landing in al-Andalus, Abd al-Rahman was greeted by clients Abu Uthman and Ibn Khalid and an escort of 300 cavalry.

Chapter 17 of William Bates ' 1920 book Perfect Sight Without Glasses, in which the author argues that observation of the sun is beneficial to those with poor vision, includes a figure of somebody " Focussing the Rays of the Sun Upon the Eye of a Patient by Means of a Burning Glass.

Upon sporulation, B. thuringiensis forms crystals of proteinaceous insecticidal δ-endotoxins ( called crystal proteins or Cry proteins ), which are encoded by cry genes.

Upon the return from Babylonia and the restoration of the Temple, YHWH will once again dwell in the new Temple as he had in the Temple built by Solomon.

A Married Women ( Restraint Upon Anticipation ) Act was passed in 1949 “ to equalise, to render inoperative any restrictions upon anticipation or alienation attached to the enjoyment of property by a woman ,” while the Married Women ( Maintenance ) Act of 1949 was enacted with the intention of improving the adequacy and duration of financial benefits for married women.

Upon activating the amulet, the player is informed of his / her past by his / her dead father, after which the player is transported to the town of Crossroads, and Part I ends.

Upon Mercer's departure, Verne Lundquist joined the network, and became their play-by-play announcer by 1977, serving eight years in that capacity before handing those chores permanently over to Brad Sham, who joined the network in 1977 as the color analyst and occasional fill-in for Lundquist.

Upon completion of his Presidential term, his commission was reactivated by Congress and Eisenhower again was commissioned a five-star general in the United States Army.

Upon his accession, Domitian revalued the Roman currency by increasing the silver content of the denarius by 12 %.

Upon the death of Domitian, Nerva was proclaimed Emperor by the Roman Senate | Senate.

Upon disconnecting, the IP address is returned to the pool for use by another computer.

Roger Ebert approves of the use of the label in unsuccessful films that had been tampered with by studio executives, such as Sergio Leone's original cut of Once Upon a Time in America, and the moderately successful theatrical version of Daredevil, which were altered by studio interference for their theatrical release.

Upon orbital insertion around Jupiter, however, David Bowman is confronted with a huge, black featureless monolith with the exact proportions of 1 by 4 by 9 ( the squares of the first three positive integers ).

Upon Ivan's death, he was succeeded by his simple-minded son Feodor.