By 1566, Aldus Manutius the Younger was able to state that the main object of punctuation was the clarification of syntax.

By 1566, the chapel was located on the south side of the quadrangle, as shown in a drawing made for Elizabeth I's visit to Oxford in that year.

By the middle of the 16th century, the official full style of the reigning Ottoman Emperor had been stablished, remaining the same until the fall of the dynasty ; e. g. in 1566, Sultan Suleyman the Magnificent was styled:

By July 1566 he was serving in Ireland under the command of Sidney ( then Lord Deputy ) against Shane O ' Neill, but was sent to England later in the year with dispatches for the Queen.

By his second wife, Rachel de Cochefilet ( 1566 – 1659 ), the widow of François Hurault, Lord of Chateaupers, whom he married in 1592 and who turned Protestant to please him, he had nine children, of whom six died young.

By the mid 17th century, numerous small Dutch and Flemish distillers ( some 400 in Amsterdam alone by 1663 ) had popularized the re-distillation of malt spirit or wine with juniper, anise, caraway, coriander, etc., which were sold in pharmacies and used to treat such medical problems as kidney ailments, lumbago, stomach ailments, gallstones, and gout.

By the time he became emperor, he had chronic gout and could hardly walk.

By late 1617, Anne's bouts of illness had become debilitating ; the letter writer John Chamberlain recorded: " The Queen continues still ill disposed and though she would fain lay all her infirmities upon the gout yet most of her physicians fear a further inconvenience of an ill habit or disposition through her whole body ".

By 1539, Antoine suffered from gout and asked his niece, Mary of Guise, to send him a Scottish hackney horse which he hoped to find easier to ride with his condition.

By A Game of Thrones, he is in his fifties ; and his gout leaves him barely able to walk and dependent on a wheeled chair.

By `` image '' is meant not only a visual presentation, but also remembered sensations of any of the five senses plus the feelings which are immediately conjoined therewith.

By virtue of his self-reliance, his individualism and his freedom from external restraint, the private eye is a perfect embodiment of the middle class conception of liberty, which amounts to doing what you please and let the devil take the hindmost.

By no means would we discourage the production of ideas: they provide raw materials with which to work ; ;

By distinguishing superlunary ( celestial ) and sublunary ( terrestrial ) existence, and reinforcing this with the four-element physics of Empedocles, Aristotle came to speak of the stars as perfect bodies, which moved in only a perfect way, viz. in a perfect circle.

By early June they were a hundred miles off the coast of Ceylon, by which time all four missionaries were hardened seafarers.

By late afternoon the train inched into the marshaling yards in the railhead at Lublin, which was filled with lines of cars poised to pour the tools of war to the Russian front.

By odd coincidence, on the evening of her return Shelley chose to read Parisina, which was the latest of the titled poet's successes.

By making inroads in the name of law enforcement into the protection which Congress has afforded to the marriage relationship, the Court today continues in the path charted by the recent decision in Wyatt v. United States, 362 U.S. 525, where the Court held that, under the circumstances of that case, a wife could be compelled to testify against her husband over her objection.

By combining the talents of a medical man, Dr. Aterman, a biophysicist, Mr. Berkely, and an electronics expert, Dr. Zworykin, this novel technique has been developed which promises to open broad avenues to understanding life processes.

By Theorem 10, D is a diagonalizable operator which we shall call the diagonalizable part of T.

By ( 1 ), the image of this pencil is a ruled surface of order Af which is met by the plane of the pencil in a curve, C, of order Af.

By the end of the spring of 1961, assuming that a general business recovery gets under way, interest rates should begin to edge upward again, depending upon the vigor of the recovery and the determination with which the monetary authorities move to restrain credit availability.

By the very nature of the situation, it is the union which has been able to select the time and place to bring pressure upon management.

By all means the most important distinction is that between those total-cost apportionments which superimpose a distribution of admittedly unallocable cost residues on estimates of incremental or marginal costs, and those other apportionments which recognize no difference between true cost allocation and mere total-cost distribution.

By the time Felix turned up it was early afternoon, which, one would think, would be late enough so that by then, except for small children and a few hardy souls who had not yet sobered up, it could have been expected that people would no longer be having any sort of active interest in the previous night's noisemakers and paper hats.

By way of explanation we ourselves are prone to imagine that this achievement stems from the same American Catholic zeal and generosity which brought the parochial school system into existence.

By the Brønsted-Lowry definition, any compound which can easily be deprotonated can be considered an acid.

By the 27th century BC Egyptian writing had a set of some 24 hieroglyphs which are called uniliterals, to represent syllables that begin with a single consonant of their language, plus a vowel ( or no vowel ) to be supplied by the native speaker.

By the Naturalisation Act 1870, it was made possible for British subjects to renounce their nationality and allegiance, and the ways in which that nationality is lost are defined.

By 1980 the infrequency of sightings of Mount Ararat, which looms about sixty kilometers across the Turkish border, became a symbol of worsening air pollution in Yerevan.

By the Rule of St Benedict, which, until the Cluniac reforms, was the norm in the West, the abbot has jurisdiction over only one community.

By studying these images, they can detect solar system objects by their movements relative to the background stars, which remain fixed.

By 325, the controversy had become significant enough that the Emperor Constantine called an assembly of bishops, the First Council of Nicaea, which condemned Arius ' doctrine and formulated the original Nicene Creed of 325.

By some estimates, this might account for most of the internal radiation damage, as the recoil nuclei are typically heavy metals which preferentially collect on the chromosomes.

By failing to do as he was told instantly -- to take out a permit or return the gun to his car -- he had played into Lord's hands.

By 1898, rustling losses had been driven down to the lowest level ever seen in Wyoming.

By the death of his father in 1888 he had come into possession of the family estate and had re-assumed its traditions.

By the time Lilian had been graduated from public school, her parents were doing quite well.

) By the time the streetcar pulled away, he had fallen in love with Paula.

By this time she had learned that it was futile to argue with her young husband, yet the uncomfortable fact remained: the American Congregationalists were sending them as missionaries to the Far East and paying their salaries.

By the age of six young Johnny indicated that he had the call.

By September 1940 the Suite had developed into a collection of six songs, `` four spirituals, a dream, and a lullaby ''.

By now he had become Regius Professor of Modern History at Cambridge and had been honored by the award of the Order of Merit.

By both standards Thomas had the right to be proud.

By June 19, 1788, he had presented himself to its Commander in Chief, the Governor of the Southern Provinces, the Director of the War College -- The Prince.

By 1783 her legions had managed to annex the Crimea amid scenes of wanton cruelty and now, in this second combat with the Crescent, were aiming at suzerainty over all of the Black Sea's northern shoreline.

By this time word had got around that an American doctor was on the premises.

By this time Woodruff had accurately measured Pike as a man of great personal pride, a man who would fly into a towering rage if his integrity were questioned, and who would be anxious to avenge himself.

By 1834 the art of oratory had reached a very high level in the United States as a literary form.

By the time he was under the covers he had forgotten about seeing Kate.

By 1937 he had clarified his intentions to serve his people: `` I have striven for clarity and melodious idiom, but at the same time I have by no means attempted to restrict myself to the accepted methods of harmony and melody.

By the time the film was released we were three million dollars over-spent, war was imminent and the public apparently had forgotten all about Mother Cabrini.

By this time Churchill was not so cordial toward moving Poland westward as he had been at Teheran, where he and Eden had both heartily approved the idea.

By December, 1958, when ' Abdallah Ibrahim became President of the Council, elections had even greater importance.

By 800 social and cultural security had been achieved, at least on a simple plane ; ;

By this time large numbers of the audience had left the hall.