Upon receptor activation, the intracellular receptor domain activates the GTPase, which in turn activates other molecules of the signal transduction chain, either via the α unit or the βγ complex.

Upon activation, a proto-oncogene ( or its product ) becomes a tumor-inducing agent, an oncogene.

Upon activation, they assign proteins to specific membrane subdomains where they participate in signaling.

Upon ligand binding, the receptor undergoes conformation changes that stimulate the enzyme adenylyl cyclase, which leads to an increase in intracellular cAMP and subsequent activation of protein kinase A.

Upon activation, K. I. Sawyer was placed under the Jurisdiction of Air Defense Command ( ADC ) on 8 April 1956.

Upon activation the normal traffic light cycle is suspended and replaced by the " preemption sequence ": the traffic lights to all approaches to the intersection are switched to " red " with the exception of the light for the vehicle that has triggered the preemption sequence.

Upon activation, the 66th, 414th and 433d Fighter Weapons Squadrons were inactivated, becoming the " A-10 ", " F-4E " and " F-15A " Divisions of the FWS.

Upon activation, TF binds with coagulation factors which then triggers the extrinsic pathway ( via Factor VII ) which subsequently triggers the intrinsic pathway ( XII to XI to IX ) of coagulation.

Upon activation, they marginate ( position themselves adjacent to the blood vessel endothelium ), and undergo selectin-dependent capture followed by integrin-dependent adhesion in most cases, after which they migrate into tissues, where they survive for 1 – 2 days.

Upon activation, it tells Sarah that it is a gift from the Doctor.

Upon activation, ERK may phosphorylate a number of cytoplasmic and nuclear molecules that ultimately result in the protein synthesis and morphological changes observed in L-LTP.

Upon activation of the spoiler, a high pressure zone is created in front of the flap, and this high pressure zone is exploited — two air intakes are revealed upon application that will allow the high pressure airflow to enter ducts that route air to aid in cooling the rear brakes.

Upon activation, AMPK increases cellular energy levels by inhibiting anabolic energy consuming pathways ( fatty acid synthesis, protein synthesis, etc.

Upon activation by thrombin, ( factor IIa ), it dissociates from the complex to interact with factor IXa in the coagulation cascade.

Upon activation, " low-affinity " IL-2 receptors are replaced by " high-affinity " IL-2 receptors consisting of α, β, and γ chains.

Upon activation by its ligand agrin, MuSK signals via two proteins called " Dok-7 " and " rapsyn ", to induce " clustering " of acetylcholine receptors ( AChR ).

Upon being called up, service members will usually be screened for their medical and personal status in order to qualify or disqualify them for activation.

Upon activation, operational units of the wing were the 367th, 368th and 369th Bombardment Squadrons under the 306th Bombardment Group which was transferred from the 307th BMW.

Upon activation, area code 954 had the distinction of being the only area code within Florida to encompass only one county.

Upon activation, data loggers are typically deployed and left unattended to measure and record information for the duration of the monitoring period.

Upon activation by PDGF, these receptors dimerise, and are " switched on " by auto-phosphorylation of several sites on their cytosolic domains, which serve to mediate binding of cofactors and subsequently activate signal transduction, for example, through the PI3K pathway.

Upon the binding of C1 to immune complexes by virtue of the affinity of C1q for immunoglobulins ( to be specific, IgM and IgG ), the controlling action of C1-In is overcome, and C1q effects activation of C1r2s2.

Upon activation, protein kinase C enzymes are translocated to the plasma membrane by RACK proteins ( membrane-bound receptor for activated protein kinase C proteins ).

Upon activation at Shaw, the 20th FW assumed the personnel and equipment of the inactivated 363d Fighter Wing.

Upon activation, Kinross-based interceptors were directed to intercept unknown aircraft by ADC surveillance Radars at Sault Sainte Marie AFS ( P-86 ); Grand Marais AFS ( M-109 ); Calumet AFS ( P-16 ); Alpena AFS ( M-105 ) and Empire AFS ( P-34 ).

Upon the outbreak of the Korean War in June 1950, OGMC was given the mission of developing a surface-to-surface ballistic missile with an objective range of.

Upon election to Scholarship ( usually in their Senior Freshman or second year ), Scholars are awarded a wide range of entitlements, including an annual salary, free rooms in college, a meal every weekday at the traditional Commons dinner, and academic fees paid or reduced.

Upon returning to Kashgar, he headed north into the Tian Shan range, surveying passes and gauging the attitudes of Kalmyk, Kazakh and Kyrgyz tribes towards the Han Chinese.

* Upon playback, the encoded material, now contaminated with noise, is passed through an expander which restores the original dynamic range of the source material.

Upon hearing about this, López called a last war council with the remaining officers of his general staff in order to decide the course of action for the upcoming battle, whether they should escape into the hill range or stay and make a stand against the attackers.

" Upon admission to the hospital, she was noted as suffering from hypokalemia: her serum potassium level was an abnormally low 2. 0 mEq / L ( the normal range for adults is 3. 5 – 5. 0 mEq / L ).

Upon his return to London he is informed by M that a freighter carrying top secret NATO weapons including laser-guided surface-to-air missiles, long range missiles, missile shields, latest GPS technology and Q equipped BMW 750iL bound for Halifax was intercepted in Labrador Sea, south of Greenland.

Upon discovery of what he had done, Skywarp shot Thundercracker in the face at point blank range.

Upon entering the room, the trigger mechanism was tripped and the shotgun fired into Katko ’ s legs at point blank range.

Upon seeing It's true form ( the dead lights ), Audra becomes catatonic and Tom drops dead in shock.

Upon delivery, Ruttmann found that hot film lights often melted the wax to a serious degree.

Upon the collapse of Skase's company Qintex, he would flee the country to Spain and the flood lights would continue to be unpaid.

Upon exiting, it enters the city of Menlo Park as an expressway, where it intersects SR 114 and SR 109 at intersections controlled by traffic lights.

Upon reaching Ioribaiwa, the lead Japanese elements began to celebrate — from their vantage point on the hills around Ioribaiwa, the Japanese soldiers could see the lights of Port Moresby and the Coral Sea beyond.

Upon reaching MDA of, Lutz declared that he had " ground contact " and would continue on, then deliberately descended the plane below the minimum descent altitude ( MDA ) without having the required visual contact with either the approach lights or the runway, a major piloting error that ultimately led directly to the crash.

Upon the outbreak of World War I, he interrupted his studies and joined the British Army YMCA, which sent him to Bombay and Amhara, where he witnessed poverty and the horrors of war at first hand.

Upon reaching Bombay, Roy met leaders like Jawaharlal Nehru and Subhas Bose, the former of whom recalled that despite significant political differences, " I was attracted to him by his remarkable intellectual capacity .”

Upon his return to Bombay he was censured by the government for having spent too much on gifts for the members of the Persian court.

Upon his arrival in Bombay there is widespread agitation.

Upon his retirement from the film industry, Dilip Kumar also spent many years as a Bombay politician.