Ligands are generally bound to the central atom by a coordinate covalent bond ( donating electrons from a lone electron pair into an empty metal orbital ), and are said to be coordinated to the atom.

Ligands may also bind elsewhere, however, as is the case for bulkier ligands ( e. g., proteins or large peptides ), which instead interact with the extracellular loops, or, as illustrated by the class C metabotropic glutamate receptors ( mGluRs ), the N-terminal tail.

Ligands bind to receptors and dissociate from them according to the law of mass action.

Ligands that activate the non-canonical pathways are Wnt4, Wnt5a, and Wnt11.

Ligands may interact with DNA by covalently binding, electrostatically binding, or intercalating.

* Synthesis and Activity of Dafachronic Acid Ligands for the C. elegans DAF-12 Nuclear Hormone Receptor

Ligands that span the faces or edges of the M6 core are labeled L < sub > i </ sub >, for innen, and those ligands attached only to one metal are labeled L < sub > a </ sub >, for ausser.

Ligands for P-selectin on eosinophils and neutrophils are similar sialylated, protease-sensitive, endo-beta-galactosidase-resistant structures, clearly different than those reported for E-selectin, and suggest disparate roles for P-selectin and E-selectin during recruitment during inflammatory responses.

I don't know what makes you think you can get away with this kind of business, and I don't care about that, either.

Besides, 'tain't no more'n right for me to follow with my black oxen, so's I can unhook and pull up fast if either of you get in a pinch ''.

If Mrs. Wright doesn't accept the terms in the morning, I'll go either to Tokyo or to Holland, to do what I can.

`` The discontinuity can either be that of war to destruction, or that of diplomatic policy ''.

Pre-shaped corrugated metal sections or pre-cast concrete can be used for shelters either above or below ground.

The Peace Corps can either begin in very low gear, with only preparatory work undertaken between now and when Congress finally appropriates special funds for it -- or it can be launched now and in earnest by executive action, with sufficient funds and made available from existing Mutual Security appropriations to permit a number of substantial projects to start this summer.

Long observation has taught Mason that most landscape can be reduced to three essential planes: a foreground in sharp focus -- either a light area with dark accents or a dark one with lights ; ;

This tendency can be broken either by restoring hypothalamic excitability directly or via cortico-hypothalamic pathways.

The fact that there can not be any limit points of the set except in closed intervals follows from the argument used in Lemma 1, namely, that near any tangent point in the C-plane the curves C and Af are analytic, and therefore the difference between them must be a monotone function in some neighborhood on either side of the tangent point.

But if no two lines of the regulus of multiple secants of **zg can intersect, then the regulus must be quadratic, or in other words, **zg must be either a Af or a Af curve on a nonsingular quadric surface.

This can only be for one of two reasons: either the two are quite different and will require totally different theory ( and hence techniques ), or our existing theories are insufficiently general.

Tonal morphophonemics, in a common case, can do nothing but either raise or lower the tone.

An operational approach to sociology can never expect abstract certainty, since it is certainty which every new discovery in science either replaces or reshapes.

Blowing can be either one of two types -- carbon dioxide gas generated by the reaction of water on the polyisocyanate or mechanical blowing through the use of a low-boiling liquid such as a fluorinated hydrocarbon.

Students of the college who are candidates for the A.B. degree and can satisfy the academic requirements of the medical and business schools, may enter either of these associated schools at the beginning of senior year, thus completing the two-year postgraduate course in one year.

`` As long as Mr. Khrushchev is convinced that the balance of world power is shifting his way, no amount of either smiles or toughness, neither Camp David talks nor kitchen debates, can compel him to enter fruitful negotiations ''.

Confronted with this situation, most libraries either endure the severe limitations of their budgets and do what they can with what they have, or else depend on the bounty of patrons and local governments to supplement their annual funds.

The fear of war can make us either too weak to stand and too willing to compromise, or too reckless and too nervous to negotiate for peace as long as there is any chance to negotiate.

Because if you can't then nobody else can either, nobody else can have him.

The cakes are marketed and can the found in cities either in Algeria or in Europe or North America.

Animation can be made with either hand rendered art, computer generated imagery, or three-dimensional objects, e. g. puppets or clay figures, or a combination of techniques.

Most frogs can be classified as either prolonged or explosive breeders.

Damage to either of these areas can reduce the fitness of the rival, either because of the need to regenerate tissue or because it impairs its ability to detect food.

I think I have a way so we can carry on without his suspecting us ''.

`` If you can conveniently let me have twenty dollars '', he wrote one friend in 1791 when he was Secretary of the Treasury.

We have staved off a war and, since our behavior has involved all these elements, we can only keep adding to our ritual without daring to abandon any part of it, since we have not the slightest notion which parts are effective.

But now we can keep it out no longer, because we have come into a time when `` it invades our experience at every moment.

indeed, it is maintained that the sexual element in jazz, by freeing the listener of his inhibitions, can have therapeutic value.

All such imitations of negative quality have given rise to a compensatory response in the form of a heroic and highly individualistic humanism: if man can neither know nor love reality as it is, he can at least invent an artistic `` reality '' which is its own world and which can speak to man of purely personal and subjective qualities capable of being known and worthy of being loved.

This is an unsolved problem which probably has never been seriously investigated, although one frequently hears the comment that we have insufficient specialists of the kind who can compete with the Germans or Swiss, for example, in precision machinery and mathematics, or the Finns in geochemistry.

We hear equally fervent concern over the belief that we have not enough generalists who can see the over-all picture and combine our national skills and knowledge for useful purposes.

But, for practical purposes, we have people who can be considered as such.

Men continuously at the head of growing enterprises can acquire experiences of the most varied, complicated and trying type so that at maturation they have developed the competence and willingness to accept the personal responsibility so sorely needed now.

Only recently, and perhaps because a television debate can so effectively dramatize President Kennedy's extraordinary mastery of detail, have the abilities on which the capacity for making distinctions depend begun to be clearly discernible at the level of politics.

This means that the inception of change itself can begin only when the factors conducive to change have already become more powerful than those anchoring the existent form in being.

Without saying or seeming to say that in portraying the Sartoris and the Compson families Faulkner's chief concern is social criticism, we can say nevertheless that through those families he dramatizes his comment on the planter dynasties as they have existed since the decades before the Civil War.

If our sincerity is granted, and it is granted, the discrepancy can only be explained by the fact that we have come to believe hearsay and legend about ourselves in preference to an understanding gained by earnest self-examination.

We feel uncomfortable at being bossed by a corporation or a union or a television set, but until we have some knowledge about these phenomena and what they are doing to us, we can hardly learn to control them.

The men who speculate on these institutions have, for the most part, come to at least one common conclusion: that many of the great enterprises and associations around which our democracy is formed are in themselves autocratic in nature, and possessed of power which can be used to frustrate the citizen who is trying to assert his individuality in the modern world ''.

I still have the dress, and I hope to give it to the Smithsonian Institution as a memento, or, as I more fondly hope, to present it to a museum containing articles showing the daily lives of the Presidents -- if I can get it organized.

Conventional images of Jews have this in common with all perceptions of a configuration in which one feature is held constant: images can be both true and false.

Certainly one of the most important comments that can be made upon the spiritual and cultural life of any period of Western civilization during the past sixteen or seventeen centuries has to do with the way in which its leaders have read and interpreted the Bible.

`` Mr. Lane '', Hearst said, `` if you ever wish anything that I can do, all you will have to do will be to send me a telegram asking, and it will be done ''.

In my experience the assurance of forgiveness comes only when I have confessed to the wronged one and have made as full reparation as I can devise.