* 1621 – Cristofano Allori, Italian painter ( b. 1577 )

* 1621 – Guillaume du Vair, French writer ( b. 1556 )

* 1621 – Gerbrand van den Eeckhout, Dutch painter ( d. 1674 )

He was the father of the painter Cristofano Allori ( 1577 – 1621 ).

* 1578 – Philip III of Spain ( d. 1621 )

* 1682 – Avvakum, Russian priest and writer ( b. 1621 )

* 1621 – The Mayflower sets sail from Plymouth, Massachusetts on a return trip to England.

Ambrosius Bosschaert the Elder ( 18 January 1573 – 1621 ) was a still life painter of the Dutch Golden Age.

* 1621 – Roger Boyle, 1st Earl of Orrery, English soldier, statesman, and dramatist ( d. 1679 )

(; 4 October 1542 – 17 September 1621 ) was an Italian Jesuit and a Cardinal of the Catholic Church.

Under Pope Paul V ( reigned 1605 – 1621 ), a major conflict arose between Venice and the Papacy.

* 1621 – Saint Job of Maniava, Ukrainian Orthodox Saint ( b. 1550 )

* 1621 – Katarina Stenbock, Queen of Gustav I of Sweden ( b. 1535 )

* 1621 – Rebecca Nurse, English colonist executed during Salem witch trials ( d. 1692 )

* 1571 – Michael Praetorius, German composer ( d. 1621 )

* 1621 – Myles Standish is appointed as first commander of Plymouth colony.

* 1621 – Johannes Schefferus, Alsatian humanist ( d. 1679 )

* 1621 – Gregory XV becomes Pope, the last Pope elected by acclamation.

During the 17th century, the French fabulist Jean de La Fontaine ( 1621 – 1695 ) saw the soul of the fable in the moral — a rule of behavior.

* Jean de La Fontaine ( French, 1621 – 95 ).

* 1621-Second battle of Gibraltar on which a Spanish squadron crushed the VOC at the strait of Gibraltar – Battle of Gibraltar ( 1621 )

Galileo initially called his discovery the Cosmica Sidera (" Cosimo's stars "), in honour of Cosimo II de ' Medici ( 1590 – 1621 ).

In his reign ( 1598 – 1621 ) a ten year truce with the Dutch was overshadowed in 1618 by Spain's involvement in the European-wide Thirty Years ' War.

Philip III was succeeded in 1621 by his son Philip IV of Spain ( reigned 1621 – 1665 ).

* January 9 – Charles Bonaventure de Longueval, Count of Bucquoy, soldier in Habsburg service ( d. 1621 )

* August 5 – Charles de Luynes, first duke of Chaulnes ( d. 1621 )

Charles de Luynes ( 1578 – 1621 ), royal favourite, 1617 – 21.

Twenty-eight Bohemian nobles were executed at Old Town Hall ( Prague ) on 21 June 1621, and the heads of twelve of them, along with the hand of Joachim Andreas von Schlick were nailed to the Old Town Tower of Charles Bridge, where they remained for ten years.

In 1621 the chancellor's eldest son, Sir Robert, married Eleanor, daughter of Sir Francis Rushe, whose sisters, Mary and Anne respectively, married Sir Charles Coote and Sir George Wentworth, the lord deputy's brother.

In November 1621, roused by Sir Edward Coke, they framed a petition asking not only for war with Spain but also for Prince Charles to marry a Protestant, and for enforcement of the anti-Catholic laws.

Charles d ' Albert, Duke of Luynes ( 5 August 1578 – Longueville, 15 December 1621 ), was a favourite of Louis XIII who was made a Peer of France and Constable of France before dying at the height of his influence.

Anthony Ashley Cooper, 1st Earl of Shaftesbury PC ( 22 July 1621 – 21 January 1683 ), known as Anthony Ashley Cooper from 1621 to 1631, as Sir Anthony Ashley Cooper, 2nd Baronet from 1631 to 1661, and as The Lord Ashley from 1661 to 1672, was a prominent English politician during the Interregnum and during the reign of King Charles II.

* Charles II de Cossé, Duke of Brissac ( 1562 – 1621 ), Marshal of France

* Charles de Créquy, Prince of Poix, Duke of Lesdiguières ( 1580 – 1638 ), Marshal of France in 1621.

He became President of the Council in 1621, in which office he was continued by Charles I, who created him Earl of Manchester in 1626.

In the 1620s a group of Scots was sent by Charles I to set up a colony, and the Latin name is used in Sir William Alexander's 1621 land grant.

In November 1621, led by Sir Edward Coke, the Commons framed a petition asking not only for a war with Spain but for Prince Charles to marry a Protestant, and for enforcement of the anti-Catholic laws.

Charles wanted to endow Naples with a new and larger theatre to replace the old and dilapidated Teatro San Bartolomeo of 1621.

Charles Bonaventure de Longueval, Count of Bucquoy ( Czech Karel Bonaventura Buquoy, full name in French Charles Bonaventure de Longueval comte de Bucquoy, German: Karl Bonaventura Graf von Buquoy ) ( Arras, 9 January 1571 – Nové Zámky, 10 July 1621 ) was a military commander who fought for the Holy Roman Empire during the Thirty Years ' War.

* Charles II Gonzaga ( 1621 – 1631 )

* Jan Jesenius ( 1566 – 1621 ), Slovak physician, philosopher and politician, rector of Charles University in Prague

His vanity, avarice, and irascibility soon lost him his English friends ; the projected Spanish marriage of Prince Charles made him anxious about the security of his position in England, and the election of Pope Gregory XV ( 9 February 1621 ) furnished him with an occasion of intimating, through Catholic diplomatists in England, his wish to return to Rome.

* Charles d ' Albert, duc de Luynes ( 1621 ), 1621

He was appointed one of the Gentlemen of the Bedchamber to Charles I of England when a young man, and was knighted by the King as appears by a charter under the great seal, dated 5 June 1621.

* Charles Howard, 2nd Earl of Nottingham 27 July 1621 – 1642 jointly with