Ligands that activate the non-canonical pathways are Wnt4, Wnt5a, and Wnt11.

Ligands that span the faces or edges of the M6 core are labeled L < sub > i </ sub >, for innen, and those ligands attached only to one metal are labeled L < sub > a </ sub >, for ausser.

Ligands for P-selectin on eosinophils and neutrophils are similar sialylated, protease-sensitive, endo-beta-galactosidase-resistant structures, clearly different than those reported for E-selectin, and suggest disparate roles for P-selectin and E-selectin during recruitment during inflammatory responses.

Ligands may also bind elsewhere, however, as is the case for bulkier ligands ( e. g., proteins or large peptides ), which instead interact with the extracellular loops, or, as illustrated by the class C metabotropic glutamate receptors ( mGluRs ), the N-terminal tail.

Ligands may interact with DNA by covalently binding, electrostatically binding, or intercalating.

* Systematic Evolution of Ligands by Exponential Enrichment, a molecular biology technique used in drug development

Ligands bind to receptors and dissociate from them according to the law of mass action.

Ligands can either have non-cooperativity, positive cooperativity or negative cooperativity.

* Synthesis and Activity of Dafachronic Acid Ligands for the C. elegans DAF-12 Nuclear Hormone Receptor

Business loans generally are repayable in regular installments -- usually monthly, including interest at the rate of 5-1/2 percent per annum on the unpaid balance -- and have a maximum maturity of 10 years ; ;

Taxation of tangible movable property in Rhode Island has been generally of a `` hands off '' nature due possibly to several reasons: ( 1 ) local assessors, in the main, are not well paid and have inadequate office staffs, ( 2 ) the numerous categories of this component of personal property make locating extremely difficult, and ( 3 ) the inexperience of the majority of assessors in evaluating this type of property.

With respect to other frequencies, these are designated as regional or local, and assigned for use by class 3, and class 4, stations, respectively, stations operating generally with lower power.

The basic costs are generally pretty much the same regardless of the agency through which you reserve your car, but some of them offer supplementary advantages.

The civil services in such societies are generally inadequate to deal competently with the problems facing them ; ;

In small-town people are very friendly dominant stress will generally be on the complement very friendly ; ;

The great majority of present-day linguists fall into one or more of a number of overlapping types: those who are convinced that tone cannot be analysed, those who are personally scared of tone and tone languages generally, those who are convinced that tone is merely an unnecessary marginal feature in those languages where it occurs, those who have no idea how to proceed with tone analysis, those who take a simplistic view of the whole matter.

The bulk of the preparation had, of course, proceeded under the supervision of the Ministry of the Interior, whose officials are barred from party activity and probably generally disinterested in party politics.

In general, it appears that trustees and board members attempt to represent the public interest in their administration of educational policy, and this is made easier by the fact that the dominant values of the society are middle-class values, which are generally thought to be valid for the entire society.

The grand jury commented on a number of other topics, among them the Atlanta and Fulton County purchasing departments which it said `` are well operated and follow generally accepted practices which inure to the best interest of both governments ''.

While availability of mortgage money has been a factor in encouraging apartment construction, the generally high level of prosperity in the past few years plus rising consumer income are among the factors that have encouraged builders to concentrate in the apartment-building field.

The reason, says the Housing Center, is that the builders invited to the intentions conference `` are generally among the more successful businessmen, and usually do somewhat better than their fellow builders ''.

The terms are generally taken for granted as though they referred to direct and axiomatic elements in the common experience of all.

But Mr. Bragg is a remarkably gifted conductor, and the results he has produced with his boys are generally superior.

The ballads are sweet and sad, and the music generally competent.

The reasons are that America generally believes that she can buy anything with dollars, and that she compulsively strives to be liked.

The works that have survived are in treatise form and were not, for the most part, intended for widespread publication, as they are generally thought to be lecture aids for his students.

E. B. Tylor ( 2 October 1832 – 2 January 1917 ) and James George Frazer ( 1 January 1854 – 7 May 1941 ) are generally considered the antecedents to modern social anthropology in Britain.

Modern discussions of alchemy are generally split into an examination of its exoteric practical applications, and its esoteric aspects.

In practice, the estimates of treatment-effects from observational studies generally are often inconsistent.

... review, on the other hand, provide an independent and civil inquiry into the validity of a conviction and sentence, and as such are generally limited to challenges to constitutional, jurisdictional, or other fundamental violations that occurred at trial.

In Britain, obviously, the archaeological and place-name characteristics of the Saxon Shore region are bound to be Saxon.

It would seem, then, that movable property and equipment is not taxed as a whole but that certain types are taxed in towns where this is bound to be expedient for that particular kind of personal property.

Distribution costs are almost bound to increase in the sixties -- and you will never know what you can do to control them unless you study each element and experiment with alternative ways of doing the job.

`` You are bound to get involved with people when you have children '', Fran had told me at our first meeting, `` so it is good to know that those with whom you get involved are not just dreary little housewives and dull husbands, but People Who Do Things ''.

Our efforts to overcome the lead of the Russians in space are bound to mean accelerated Federal spending.

The data are presented in text and tables in bound volumes.

In an appeal on the record from a decision in a judicial proceeding, both appellant and respondent are bound to base their arguments wholly on the proceedings and body of evidence as they were presented in the lower tribunal.

The Aegean Islands are within the sea and some bound it on its southern periphery, including Crete and Rhodes.

It was the mutual bond and obligation between monarch and subjects, whereby subjects are called his liege subjects, because they are bound to obey and serve him ; and he is called their liege lord, because he should maintain and defend them ( Ex parte Anderson ( 1861 ) 3 El & El 487 ; 121 ER 525 ; China Navigation Co v Attorney-General ( 1932 ) 48 TLR 375 ; Attorney-General v Nissan 1 All ER 629 ; Oppenheimer v Cattermole 3 All ER 1106 ).

The electrons of an atom are bound to the nucleus by the electromagnetic force.

Electrons that are bound to atoms possess a set of stable energy levels, or orbitals, and can undergo transitions between them by absorbing or emitting photons that match the energy differences between the levels.

The real numbers are uniquely picked out ( up to isomorphism ) by the properties of a Dedekind complete ordered field, meaning that any nonempty set of real numbers with an upper bound has a least upper bound.

Electrons that populate a shell are said to be in a bound state.

There are exceptions to this title ; many private clubs and religious organizations may not be bound by Title III.

They are bound morphemes by definition ; prefixes and suffixes may be separable affixes.

These tumor suppressing proteins regulate the cell cycle, but are rendered inactive when bound to an inhibitory protein.

In the practice of ahimsa, the requirements are less strict for the lay persons who have undertaken anuvrata ( Lesser Vows ) than for the monastics who are bound by the Mahavrata " Great Vows ".

In infinite space many civilizations are bound to exist, among them civilizations that are also wiser and more " successful " than ours.

For curves given by the graph of a function, horizontal asymptotes are horizontal lines that the graph of the function approaches as x tends to Vertical asymptotes are vertical lines near which the function grows without bound.