By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

By such innocent actions are human tragedies sometimes set in motion.

By the middle of the summer, many of the larvae apparently receive such a good diet that it is `` optimal '', and it is then that young queens begin to appear.

By permitting freshman students we might extend the opportunity for such a course to some individuals who otherwise might never get to take it.

By 1960 there were such schools in all but 4 states.

By seeing such varied places, both interesting and beautiful, you will become aware of the many different civilizations Rome has lived through, and in particular, get a feel of Renaissance Rome.

By such touches the pattern takes shape.

By the end of the century the Roman Catholic Church was beginning to make itself felt, mainly through such institutions as hospitals but also through its attitude towards organized labour.

By the 1850s, slavery was still legal in the southern United States, but had been generally outlawed in the northern states, such as Illinois.

By the 1970s the authors of volumes such as Reinventing Anthropology worried about anthropology's relevance.

By 1865, following the American Civil War, stocks in small industrial companies, such as iron and steel, textiles and chemicals were first sold by curbstone brokers.

Proof: By symmetry, it suffices to prove that there is some constant c such that for all bitstrings s

By " art " we may frame several artistic " works " or " creations " as so though this reference remains within the institution or special event which creates it and this leaves some works or other possible " art " outside of the frame work, or other interpretations such as other phenomenon which may not be considered as " art ".

" Caplan comments on the impact of the Supreme Court's decision making it necessary for there to be evidence of guilt in such a plea, " By requiring that there be some evidence of guilt in such a situation, the decision attempts to protect the ' really ' innocent from the temptations to which plea-bargaining and defense attorneys may subject them.

By the late 1940s it was known that the properties of atomic nucleus could not be explained by the then-current models ( such as the liquid drop model developed by Niels Bohr amongst others ).

By making the mass number of soldiers blend within the landscape / painting, it shows that he believed that the usage and depiction of landscape was just as significant as a historical event, such as a war.

* By transcending such imaginative pictures, the meditant can become conscious of the meditative activity itself, which leads to experiences of expressions of soul-spiritual beings unmediated by sensory phenomena or qualities.

* By intensifying the will-forces through exercises such as a chronologically reversed review of the day's events, the meditant can achieve a further stage of inner independence from sensory experience, leading to direct contact, and even union, with spiritual beings (" Intuition ") without loss of individual awareness.

By association, artillery may also refer to the arm of service that customarily operates such engines.

By sweeping this surface through R < sup > 3 </ sup > as a function of the ion sequence input data, such as via ion-ordering, a volume is generated onto which positions the 2D detector positions can be computed and placed three-dimensional space.

By the 2nd century there were also famous Christian ascetics, such as Saint Thecla.

By the mid late 18th century developments in cheaper zinc distillation such as John-Jaques Dony's horizontal furnaces in Belgium and the reduction of tariffs on zinc as well as demand for corrosion resistant high zinc alloys increased the popularity of speltering and as a result cementation was largely abandoned by the mid 19th century.

By comparison Whorf's other work in linguistics, the development of such concepts as the allophone and the cryptotype, and the formulation of " Whorf's law " in Uto-Aztecan historical linguistics, have met with broad acceptance.

By contrast, in mainstream Analytical philosophy the topic is more confined to abstract investigation, in the work of such influential theorists as W. V. O. Quine, to name one of many.

By 1995, many of the DOS-based BBSes had begun switching to modern multitasking operating systems, such as OS / 2, Windows 95, and Linux.