By 2008, sales in the US reached $ 14. 6 billion, the biggest selling drugs in the US by therapeutic class.

By expanding the conditions for which they were indicated, Astrazeneca's Seroquel and Eli Lilly's Zyprexa had become the biggest selling antipsychotics in 2008 with global sales of $ 5. 5 billion and $ 5. 4 billion respectively.

By 2008, numerous service areas and petrol stations had been constructed along all Croatian motorways.

By late 2008, the helmet had been dented almost beyond recognition.

By 2008, Dartmouth had graduated 238 classes of students and has over 60, 000 living alumni in a variety of fields.

By April 2008 two songs off this album were posted online.

By July 2008 various blogs referred to " an e-mail " from a colleague of the band's attorney that suggested the issue was " amicably resolved ".

By comparison, recent figures ( as of 14 November 2008 ) estimate Zimbabwe's annual inflation rate at 89. 7 sextillion ( 10 < sup > 21 </ sup >) percent., which corresponds to a monthly rate of 5473 %, and a doubling time of about five days.

By 2008, Hummer's viability in the economic downturn was being questioned, and it was placed under review by GM management.

By April 2008, whereupon he reached two years ' seniority, Harry was promoted to the rank of lieutenant.

By 2007 the " Bjäre julmust " was only sold at McDonald's restaurants and it had completely disappeared from Coca-Colas range of products by Christmas 2008, only to return for Christmas 2011.

* 2008: Gamma Player Compilation Vol 1: The Universe By Night

By comparison, in 2008 Koenigsegg with its staff of 45 produced 18 cars at an average price of US $ 1 million each ; Saab employed 3, 400 workers and made more than 93, 000 cars.

By the end of 2008, parties had a hard time agreeing on further budget cuts, ( mainly in the social sphere ) the planned reorganization of the government, and layoffs.

By 2008, worldwide sales of televisions with LCD screens exceeded annual sales of CRT units ; the CRT became obsolete for most purposes.

By 2008 there were at least six institutions monitoring lake water health: 1 ) In 2002 the Conservation Law Foundation appointed a " lakekeeper " who criticizes the state's pollution controls, 2 ) Friends of Missisquoi Bay was formed in 2003, 3 ) the Lake Champlain Committee, 4 ) Vermont Water Resources Board

By contrast, a previous study in 2008 had found only 38 percent of lemur species were at risk of extinction.

By 2008, most North American minivans had adopted the size and configuration of the long-wheelbase Chrysler vans, with Chrysler dropping their shorter models as well.

By 2008, more than 815, 000 vessels had passed through the canal, many of them much larger than the original planners could have envisioned ; the largest ships that can transit the canal today are called Panamax.

By 2008 there were several hundred casinos world wide offering roulette games.

By 2008, approximately 80 % to 90 % of commercially made cheeses in the US and Britain were made using FPC.

By 2008, these state-owned corporations had become increasingly dynamic and generated large increases in revenue for the state, resulting in a state-sector led recovery during the 2009 financial crises while accounting for most of China's economic growth.

By language, according to 2008 data, 21 % of the population always speak in Galician, 15 % always speak in Spanish and the rest use both interchangeably.

By 2008, the economy was 16. 7 times the size it was in 1978, and 12. 1 times its previous per capita levels.

By the opening of the 2008 General Conference, total UMC membership was estimated at 11. 4 million, with about 7. 9 million in the U. S. and 3. 5 million overseas.

Suggest the following twenty-first-century amendment: By moving the term `` Republic '' to lower case, substituting the modern phrase, `` move ahead '' for the stodgy `` keep '', and by using the Postmaster's name on every envelope ( in caps, of course, with the `` in spite '' as faded as possible ), the slogan cannot fail.

By the 1940s, the term commonly was capitalized, Negro, but by the mid 1960s it was considered disparaging.

By extension, the term " embark " literally means to board the kind of boat called a " barque ".

By extension, the term is also used to refer to any system administrator who displays ( or wishes he could get away with ) the qualities of the original.

By that time, the majority of black people were U. S .- born, so use of the term " African " became problematic.

By 1800, the term was practically extinct.

Coal ( from the Old English term col, which has meant " mineral of fossilized carbon " since the 13th century ) is a combustible black or brownish-black sedimentary rock usually occurring in rock strata in layers or veins called coal beds By comparison in 2007, natural gas provided of oil equivalent per day, while oil provided per day.

By extension, the term equinox may denote an equinoctial point.

By the English Middle Ages the term had been expanded to include not only the message, but also the New Testament which contained the message, as well as more specifically the four books of the Bible in which the life, death and resurrection of Jesus are portrayed.

By the time of the Protestant Reformation, Protestant theologians began to embrace the term evangelical as referring to " gospel truth ".

By analogy with the word " conlang ", the term conworld is used to describe these fictional worlds, inhabited by fictional constructed cultures.

By the late 1850s, one of these mentions the term " French fried potatoes ".

By the start of the fourteenth century the word appeared in English texts, indicating all three senses: the most common one, the legal term and the archaic usage.

By the 18th century, the term had gained its now common usage in France, and had begun to be used to refer purely to books of magic, which Owen Davies presumed was because " many of them continued to circulate in Latin manuscripts.

By the Hellenistic period, it began to also be associated with Greco-Roman mystery cults and ceremonies, becoming synonymous with the Greek term musterion.

By analogy with the ancient Greek term for agriculture, geoponics, the science of cultivating the earth, Gericke coined the term hydroponics in 1937 ( although he asserts that the term was suggested by W. A. Setchell, of the University of California ) for the culture of plants in water ( from the Greek hydro -, " water ", and ponos, " labour ").

By the turn of the twentieth century it had begun to be displaced by the shorter and purely Arabic term Islam and by 1938, when Orientalist scholars completed The Encyclopaedia of Islam, seems to have virtually disappeared from the English language.

By 1913 there were four planes, now including a British Sopwith and long term plans to create six naval air stations by 1918.

By analogy, the term letter is sometimes used for e-mail messages with a formal letter-like format.

By the time of the French Revolution some, such as the Enragés, began to use the term positively, in opposition to Jacobin centralisation of power, seeing " revolutionary government " as oxymoronic.

By the mid-15th century the term lollard had come to mean a heretic in general.

By extension, the term " Old Mandarin " is used by linguists to refer to the northern dialects recorded in materials from the Yuan dynasty.

By extension, the term " manichean " is widely applied ( often disparagingly ) as an adjective to a philosophy or attitude of moral dualism, according to which a moral course of action involves a clear ( or simplistic ) choice between good and evil, or as a noun to people who hold such a view.